dc.contributor.author | Weber, Georg F. | en_US |
dc.contributor.author | Chousterman, Benjamin G. | en_US |
dc.contributor.author | Hilgendorf, Ingo | en_US |
dc.contributor.author | Robbins, Clinton S. | en_US |
dc.contributor.author | Theurl, Igor | en_US |
dc.contributor.author | Gerhardt, Louisa M.S. | en_US |
dc.contributor.author | Iwamoto, Yoshiko | en_US |
dc.contributor.author | Quach, Tam D. | en_US |
dc.contributor.author | Ali, Muhammad | en_US |
dc.contributor.author | Chen, John W. | en_US |
dc.contributor.author | Rothstein, Thomas L. | en_US |
dc.contributor.author | Nahrendorf, Matthias | en_US |
dc.contributor.author | Weissleder, Ralph | en_US |
dc.contributor.author | Swirski, Filip K. | en_US |
dc.date.accessioned | 2015-01-05T18:27:39Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Weber, G. F., B. G. Chousterman, I. Hilgendorf, C. S. Robbins, I. Theurl, L. M. Gerhardt, Y. Iwamoto, et al. 2014. “Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis.” The Journal of Experimental Medicine 211 (6): 1243-1256. doi:10.1084/jem.20131471. http://dx.doi.org/10.1084/jem.20131471. | en |
dc.identifier.issn | 0022-1007 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581145 | |
dc.description.abstract | Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show that in response to lung infection, B1a B cells migrate from the pleural space to the lung parenchyma to secrete polyreactive emergency immunoglobulin M (IgM). The process requires innate response activator (IRA) B cells, a transitional B1a-derived inflammatory subset which controls IgM production via autocrine granulocyte/macrophage colony-stimulating factor (GM-CSF) signaling. The strategic location of these cells, coupled with the capacity to produce GM-CSF–dependent IgM, ensures effective early frontline defense against bacteria invading the lungs. The study describes a previously unrecognized GM-CSF-IgM axis and positions IRA B cells as orchestrators of protective IgM immunity. | en |
dc.language.iso | en_US | en |
dc.publisher | The Rockefeller University Press | en |
dc.relation.isversionof | doi:10.1084/jem.20131471 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042649/pdf/ | en |
dash.license | LAA | en_US |
dc.title | Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | The Journal of Experimental Medicine | en |
dash.depositing.author | Chousterman, Benjamin G. | en_US |
dc.date.available | 2015-01-05T18:27:39Z | |
dc.identifier.doi | 10.1084/jem.20131471 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Chousterman, Benjamin | |
dash.contributor.affiliated | Weissleder, Ralph | |
dash.contributor.affiliated | Swirski, Filip | |
dash.contributor.affiliated | Chen, John | |
dash.contributor.affiliated | Nahrendorf, Matthias | |