Vagus nerve controls resolution and pro-resolving mediators of inflammation

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Vagus nerve controls resolution and pro-resolving mediators of inflammation

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Title: Vagus nerve controls resolution and pro-resolving mediators of inflammation
Author: Mirakaj, Valbona; Dalli, Jesmond; Granja, Tiago; Rosenberger, Peter; Serhan, Charles N.

Note: Order does not necessarily reflect citation order of authors.

Citation: Mirakaj, Valbona, Jesmond Dalli, Tiago Granja, Peter Rosenberger, and Charles N. Serhan. 2014. “Vagus nerve controls resolution and pro-resolving mediators of inflammation.” The Journal of Experimental Medicine 211 (6): 1037-1048. doi:10.1084/jem.20132103. http://dx.doi.org/10.1084/jem.20132103.
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Abstract: Resolution of inflammation is now recognized as a biosynthetically active process involving pro-resolving mediators. Here, we show in zymosan-initiated peritoneal inflammation that the vagus nerve regulates local expression of netrin-1, an axonal guidance molecule that activates resolution, and that vagotomy reduced local pro-resolving mediators, thereby delaying resolution. In netrin-1+/− mice, resolvin D1 (RvD1) was less effective in reducing neutrophil influx promoting resolution of peritonitis compared with Ntn1+/+. Netrin-1 shortened the resolution interval, decreasing exudate neutrophils, reducing proinflammatory mediators, and stimulating the production of resolvins, protectins, and lipoxins. Human monocytes incubated with netrin-1 produced proresolving mediators, including resolvins and lipoxins. Netrin-1 and RvD1 displayed bidirectional activation in that they stimulated each other’s expression and enhanced efferocytosis. These results indicate that the vagus nerve regulates both netrin-1 and pro-resolving lipid mediators, which act in a bidirectional fashion to stimulate resolution, and provide evidence for a novel mechanism for local neuronal control of resolution.
Published Version: doi:10.1084/jem.20132103
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042652/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581152
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