Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma

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Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma

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Title: Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma
Author: Simpson, R Mark; Bastian, Boris C; Michael, Helen T; Webster, Joshua D; Prasad, Manju L; Conway, Catherine M; Prieto, Victor M; Gary, Joy M; Goldschmidt, Michael H; Esplin, D Glen; Smedley, Rebecca C; Piris, Adriano; Meuten, Donald J; Kiupel, Matti; Lee, Chyi-Chia R; Ward, Jerrold M; Dwyer, Jennifer E; Davis, Barbara J; Anver, Miriam R; Molinolo, Alfredo A; Hoover, Shelley B; Rodriguez-Canales, Jaime; Hewitt, Stephen M

Note: Order does not necessarily reflect citation order of authors.

Citation: Simpson, R. M., B. C. Bastian, H. T. Michael, J. D. Webster, M. L. Prasad, C. M. Conway, V. M. Prieto, et al. 2013. “Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma.” Pigment Cell & Melanoma Research 27 (1): 37-47. doi:10.1111/pcmr.12185. http://dx.doi.org/10.1111/pcmr.12185.
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Abstract: Melanoma represents a significant malignancy in humans and dogs. Different from genetically engineered models, sporadic canine melanocytic neoplasms share several characteristics with human disease that could make dogs a more relevant preclinical model. Canine melanomas rarely arise in sun-exposed sites. Most occur in the oral cavity, with a subset having intra-epithelial malignant melanocytes mimicking the in situ component of human mucosal melanoma. The spectrum of canine melanocytic neoplasia includes benign lesions with some analogy to nevi, as well as invasive primary melanoma, and widespread metastasis. Growing evidence of distinct subtypes in humans, differing in somatic and predisposing germ-line genetic alterations, cell of origin, epidemiology, relationship to ultraviolet radiation and progression from benign to malignant tumors, may also exist in dogs. Canine and human mucosal melanomas appear to harbor BRAF, NRAS, and c-kit mutations uncommonly, compared with human cutaneous melanomas, although both species share AKT and MAPK signaling activation. We conclude that there is significant overlap in the clinical and histopathological features of canine and human mucosal melanomas. This represents opportunity to explore canine oral cavity melanoma as a preclinical model.
Published Version: doi:10.1111/pcmr.12185
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066658/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581194
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