Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms
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Author
Schneider, Rebekka K
Ziegler, Susanne
Leisten, Isabelle
Ferreira, Monica SV
Schumacher, Anne
Rath, Björn
Fahrenkamp, Dirk
Müller-Newen, Gerhard
Crysandt, Martina
Wilop, Stefan
Jost, Edgar
Koschmieder, Steffen
Knüchel, Ruth
Brümmendorf, Tim H
Ziegler, Patrick
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1186/s13045-014-0092-2Metadata
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Schneider, R. K., S. Ziegler, I. Leisten, M. S. Ferreira, A. Schumacher, B. Rath, D. Fahrenkamp, et al. 2014. “Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms.” Journal of Hematology & Oncology 7 (1): 92. doi:10.1186/s13045-014-0092-2. http://dx.doi.org/10.1186/s13045-014-0092-2.Abstract
We characterized bone marrow stromal cells (BMSC) from patients with pre-fibrotic myeloproliferative neoplasms (MPN). MPN-BMSC showed decreased capacity to stimulate the proliferation of colony-forming units of normal hematopoietic stem and progenitor cells and displayed increased matrix remodelling (in particular fibronectin deposition) compared to control BMSC. This finding was confirmed in pre-fibrotic MPN bone marrow biopsies in a tissue microarray (n = 34), which stained positive for fibronectin in the absence of reticulin as a standard myelofibrosis marker. Fibronectin expression correlated significantly with reduced haemoglobin levels in MPN-patients (p = 0.007; R2 = 0.42). Our data show significant cell-intrinsic alterations in MPN-MSC and suggest that Fibronectin expression might be applicable as a biomarker for the identification of early myelofibrotic transformation in reticulin-negative MPN.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271470/pdf/Terms of Use
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