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dc.contributor.authorBrack, Andrew Sen_US
dc.date.accessioned2015-01-05T18:28:18Z
dc.date.issued2014en_US
dc.identifier.citationBrack, Andrew S. 2014. “Pax7 is back.” Skeletal Muscle 4 (1): 24. doi:10.1186/s13395-014-0024-4. http://dx.doi.org/10.1186/s13395-014-0024-4.en
dc.identifier.issn2044-5040en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13581231
dc.description.abstractTwo recent studies have reinvigorated the conversation regarding the role of Pax7 in adult satellite. Studies by Gunther et al (Cell Stem Cell 13:590–601, 2013) and Von Maltzhen et al (Proc Natl Acad Sci U S A 110:16474–16479) show that Pax7 is critical for adult satellite cell function and their contribution to muscle repair. Previously, Lepper et al (Nature 460:627–631, 2009) demonstrated that Pax7 was dispensable for adult muscle repair. In this commentary I have summarized the results from these studies, focusing on the differences in experimental paradigms that led the authors to different conclusions. I also take this opportunity to discuss the potential limitations and hurdles of Cre-lox technology that are responsible for the discrepant results.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/s13395-014-0024-4en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276024/pdf/en
dash.licenseLAAen_US
dc.subjectPax7en
dc.subjectSatellite cellen
dc.subjectSkeletal muscleen
dc.subjectRegenerationen
dc.subjectLineage tracingen
dc.subjectCreen
dc.titlePax7 is backen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalSkeletal Muscleen
dash.depositing.authorBrack, Andrew Sen_US
dc.date.available2015-01-05T18:28:18Z
dc.identifier.doi10.1186/s13395-014-0024-4*
dash.contributor.affiliatedBrack, Andrew S


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