dc.contributor.author | Gareen, Ilana F | en_US |
dc.contributor.author | Duan, Fenghai | en_US |
dc.contributor.author | Greco, Erin M | en_US |
dc.contributor.author | Snyder, Bradley S | en_US |
dc.contributor.author | Boiselle, Phillip M | en_US |
dc.contributor.author | Park, Elyse R | en_US |
dc.contributor.author | Fryback, Dennis | en_US |
dc.contributor.author | Gatsonis, Constantine | en_US |
dc.date.accessioned | 2015-01-05T18:28:24Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Gareen, Ilana F, Fenghai Duan, Erin M Greco, Bradley S Snyder, Phillip M Boiselle, Elyse R Park, Dennis Fryback, and Constantine Gatsonis. 2014. “Impact of lung cancer screening results on participant health-related quality of life and state anxiety in the National Lung Screening Trial.” Cancer 120 (21): 3401-3409. doi:10.1002/cncr.28833. http://dx.doi.org/10.1002/cncr.28833. | en |
dc.identifier.issn | 0008-543X | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581249 | |
dc.description.abstract | BACKGROUND Low-dose computed tomography (LDCT) lung screening has been associated with a 20% reduction in lung cancer mortality. A major barrier to the adoption of lung screening is the potential negative psychological impact of a false-positive (FP) screen, occurring in 20% to 50% of those screened. The objective of this study was to assess the impact of abnormal findings on health-related quality of life (HRQoL) and anxiety in the American College of Radiology (ACRIN)/National Lung Screening Trial (NLST). METHODS The NLST was a randomized screening trial comparing LDCT with chest X-ray screening (CXR). This study was part of the original protocol. A total of 2812 participants at 16 of 23 ACRIN sites who had baseline HRQoL assessments were asked to complete the Short Form-36 and the State Trait Anxiety Inventory (form Y-1) questionnaires to assess short-term (1 month) and long-term (6 months) effects of screening. FP were lung cancer–free at 1 year, and true-positives (TP) were not. RESULTS Of the total participants, 1024 (36.4%) participants were FP, 63 (2.2%) were TP, 344 (12.2%) had significant incidental findings (SIFs), and 1381 (49.1%) had negative screens. Participants had been randomized to LDCT (n = 1947) and CXR (n = 865). Short-term and long-term HRQoL and state anxiety did not differ across participants with FP, SIF, or negative screens. Short-term and long-term HRQoL were lower and anxiety was higher for TP participants compared to participants with FP, SIF, and negative screens. CONCLUSIONS In a large multicenter lung screening trial, participants receiving a false-positive or SIF screen result experienced no significant difference in HRQoL or state anxiety at 1 or at 6 months after screening relative to those receiving a negative result. Cancer 2014;120:3401–3409. © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. In a large multi-center lung screening trial, participants receiving a false positive or significant incidental finding screen result experienced no significant difference in health related quality of life or state anxiety at 1 or at 6 months after screening relative to those receiving a negative result. | en |
dc.language.iso | en_US | en |
dc.publisher | BlackWell Publishing Ltd | en |
dc.relation.isversionof | doi:10.1002/cncr.28833 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205265/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | quality of life | en |
dc.subject | anxiety | en |
dc.subject | lung cancer | en |
dc.subject | screening | en |
dc.subject | clinical trials | en |
dc.title | Impact of lung cancer screening results on participant health-related quality of life and state anxiety in the National Lung Screening Trial | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Cancer | en |
dash.depositing.author | Boiselle, Phillip M | en_US |
dc.date.available | 2015-01-05T18:28:24Z | |
dc.identifier.doi | 10.1002/cncr.28833 | * |
dash.contributor.affiliated | Boiselle, Phillip | |
dash.contributor.affiliated | Park, Elyse | |