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dc.contributor.authorDesbordes, Gaëlleen_US
dc.contributor.authorLi, Angen_US
dc.contributor.authorLoggia, Marco L.en_US
dc.contributor.authorKim, Jieunen_US
dc.contributor.authorSchalock, Peter C.en_US
dc.contributor.authorLerner, Ethanen_US
dc.contributor.authorTran, Thanh N.en_US
dc.contributor.authorRing, Johannesen_US
dc.contributor.authorRosen, Bruce R.en_US
dc.contributor.authorKaptchuk, Ted J.en_US
dc.contributor.authorPfab, Florianen_US
dc.contributor.authorNapadow, Vitalyen_US
dc.date.accessioned2015-02-02T15:31:33Z
dc.date.issued2014en_US
dc.identifier.citationDesbordes, G., A. Li, M. L. Loggia, J. Kim, P. C. Schalock, E. Lerner, T. N. Tran, et al. 2014. “Evoked itch perception is associated with changes in functional brain connectivity.” NeuroImage : Clinical 7 (1): 213-221. doi:10.1016/j.nicl.2014.12.002. http://dx.doi.org/10.1016/j.nicl.2014.12.002.en
dc.identifier.issn2213-1582en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13890591
dc.description.abstractChronic itch, a highly debilitating condition, has received relatively little attention in the neuroimaging literature. Recent studies suggest that brain regions supporting itch in chronic itch patients encompass sensorimotor and salience networks, and corticostriatal circuits involved in motor preparation for scratching. However, how these different brain areas interact with one another in the context of itch is still unknown. We acquired BOLD fMRI scans in 14 atopic dermatitis patients to investigate resting-state functional connectivity before and after allergen-induced itch exacerbated the clinical itch perception in these patients. A seed-based analysis revealed decreased functional connectivity from baseline resting state to the evoked-itch state between several itch-related brain regions, particularly the insular and cingulate cortices and basal ganglia, where decreased connectivity was significantly correlated with increased levels of perceived itch. In contrast, evoked itch increased connectivity between key nodes of the frontoparietal control network (superior parietal lobule and dorsolateral prefrontal cortex), where higher increase in connectivity was correlated with a lesser increase in perceived itch, suggesting that greater interaction between nodes of this executive attention network serves to limit itch sensation via enhanced top-down regulation. Overall, our results provide the first evidence of itch-dependent changes in functional connectivity across multiple brain regions.en
dc.language.isoen_USen
dc.publisherElsevieren
dc.relation.isversionofdoi:10.1016/j.nicl.2014.12.002en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300003/pdf/en
dash.licenseLAAen_US
dc.subjectaMCC, anterior mid-cingulate cortexen
dc.subjectAD, atopic dermatitisen
dc.subjectASL, arterial spin labelingen
dc.subjectBA, Brodmann areaen
dc.subjectBOLD, blood-oxygen-level dependenten
dc.subjectdlPFC, dorsolateral prefrontal cortexen
dc.subjectDMN, default mode networken
dc.subjectECG, electrocardiographyen
dc.subjectfcMRI, functional connectivity magnetic resonance imagingen
dc.subjectfMRI, functional magnetic resonance imagingen
dc.subjectGLM, general linear modelen
dc.subjectITCH, evoked itch resting-state scanen
dc.subjectL, leften
dc.subjectMNI, Montreal Neurological Instituteen
dc.subjectMR, magnetic resonanceen
dc.subjectPCC, posterior cingulate cortexen
dc.subjectPET, positron emission tomographyen
dc.subjectPMC, premotor cortexen
dc.subjectpMCC, posterior mid-cingulate cortexen
dc.subjectR, righten
dc.subjectREST, baseline resting-state scanen
dc.subjectS1/M1, primary sensorimotor cortexen
dc.subjectSCORAD, SCORing atopic dermatitis scaleen
dc.subjectSPL, Superior parietal lobuleen
dc.subjectVAS, visual analog scaleen
dc.subjectvlPFC, ventrolateral prefrontal cortex.en
dc.subjectAtopic dermatitisen
dc.subjectEczemaen
dc.subjectInsulaen
dc.subjectPruritusen
dc.subjectPutamenen
dc.titleEvoked itch perception is associated with changes in functional brain connectivityen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNeuroImage : Clinicalen
dash.depositing.authorDesbordes, Gaëlleen_US
dc.date.available2015-02-02T15:31:33Z
dc.identifier.doi10.1016/j.nicl.2014.12.002*
dash.authorsorderedfalse
dash.contributor.affiliatedSchalock, Peter C.
dash.contributor.affiliatedLi, Ang
dash.contributor.affiliatedLerner, Ethan
dash.contributor.affiliatedDesbordes, Gaelle
dash.contributor.affiliatedKaptchuk, Ted
dash.contributor.affiliatedNapadow, Vitaly
dash.contributor.affiliatedLoggia, Marco
dash.contributor.affiliatedRosen, Bruce


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