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dc.contributor.authorShahabi, Ahvaen_US
dc.contributor.authorCorral, Románen_US
dc.contributor.authorCatsburg, Chelseaen_US
dc.contributor.authorJoshi, Amit Den_US
dc.contributor.authorKim, Andreen_US
dc.contributor.authorLewinger, Juan Pabloen_US
dc.contributor.authorKoo, Jocelynen_US
dc.contributor.authorJohn, Esther Men_US
dc.contributor.authorIngles, Sue Aen_US
dc.contributor.authorStern, Mariana Cen_US
dc.date.accessioned2015-02-02T15:31:42Z
dc.date.issued2014en_US
dc.identifier.citationShahabi, Ahva, Román Corral, Chelsea Catsburg, Amit D Joshi, Andre Kim, Juan Pablo Lewinger, Jocelyn Koo, Esther M John, Sue A Ingles, and Mariana C Stern. 2014. “Tobacco smoking, polymorphisms in carcinogen metabolism enzyme genes, and risk of localized and advanced prostate cancer: results from the California Collaborative Prostate Cancer Study.” Cancer Medicine 3 (6): 1644-1655. doi:10.1002/cam4.334. http://dx.doi.org/10.1002/cam4.334.en
dc.identifier.issn2045-7634en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13890600
dc.description.abstractThe relationship between tobacco smoking and prostate cancer (PCa) remains inconclusive. This study examined the association between tobacco smoking and PCa risk taking into account polymorphisms in carcinogen metabolism enzyme genes as possible effect modifiers (9 polymorphisms and 1 predicted phenotype from metabolism enzyme genes). The study included cases (n = 761 localized; n = 1199 advanced) and controls (n = 1139) from the multiethnic California Collaborative Case–Control Study of Prostate Cancer. Multivariable conditional logistic regression was performed to evaluate the association between tobacco smoking variables and risk of localized and advanced PCa risk. Being a former smoker, regardless of time of quit smoking, was associated with an increased risk of localized PCa (odds ratio [OR] = 1.3; 95% confidence interval [CI] = 1.0–1.6). Among non-Hispanic Whites, ever smoking was associated with an increased risk of localized PCa (OR = 1.5; 95% CI = 1.1–2.1), whereas current smoking was associated with risk of advanced PCa (OR = 1.4; 95% CI = 1.0–1.9). However, no associations were observed between smoking intensity, duration or pack-year variables, and advanced PCa. No statistically significant trends were seen among Hispanics or African-Americans. The relationship between smoking status and PCa risk was modified by the CYP1A2 rs7662551 polymorphism (P-interaction = 0.008). In conclusion, tobacco smoking was associated with risk of PCa, primarily localized disease among non-Hispanic Whites. This association was modified by a genetic variant in CYP1A2, thus supporting a role for tobacco carcinogens in PCa risk.en
dc.language.isoen_USen
dc.publisherBlackwell Publishing Ltden
dc.relation.isversionofdoi:10.1002/cam4.334en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298391/pdf/en
dash.licenseLAAen_US
dc.subjectCYP1A2en
dc.subjectprostate canceren
dc.subjectsmokingen
dc.titleTobacco smoking, polymorphisms in carcinogen metabolism enzyme genes, and risk of localized and advanced prostate cancer: results from the California Collaborative Prostate Cancer Studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalCancer Medicineen
dash.depositing.authorJoshi, Amit Den_US
dc.date.available2015-02-02T15:31:42Z
dc.identifier.doi10.1002/cam4.334*
dash.contributor.affiliatedJoshi, Amit


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