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dc.contributor.authorWang, Liyunen_US
dc.contributor.authorSacks, Frank Men_US
dc.contributor.authorFurtado, Jeremy Den_US
dc.contributor.authorRicks, Madiaen_US
dc.contributor.authorCourville, Amber Ben_US
dc.contributor.authorSumner, Anne Een_US
dc.date.accessioned2015-02-02T15:31:51Z
dc.date.issued2014en_US
dc.identifier.citationWang, Liyun, Frank M Sacks, Jeremy D Furtado, Madia Ricks, Amber B Courville, and Anne E Sumner. 2014. “Racial differences between African-American and white women in insulin resistance and visceral adiposity are associated with differences in apoCIII containing apoAI and apoB lipoproteins.” Nutrition & Metabolism 11 (1): 56. doi:10.1186/1743-7075-11-56. http://dx.doi.org/10.1186/1743-7075-11-56.en
dc.identifier.issn1743-7075en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13890618
dc.description.abstractBackground: African-Americans have higher HDL, less visceral adipose tissue (VAT) and lower triglyceride (TG) and apoCIII concentrations than whites, despite being more insulin-resistant. We studied in African-American and white women the influences of insulin resistance and VAT on the apoAI concentrations of two HDL subspecies, one that contains apoCIII that is associated with increased risk of coronary heart disease (CHD) and one that does not have apoCIII that is associated with decreased CHD; and on the apoCIII concentrations of HDL and of the apoB lipoproteins. Methods: The participants were 32 women (14 African-Americans, 18 white) of similar age (39 ± 12 vs. 42 ± 11y). Mean BMI was 34 kg/m2 in the African-Americans compared to 30 in the whites. A standard diet (33% fat, 52% carbohydrate, 15% protein) was provided for 7 days followed by a test meal (40% fat, 40% carbohydrate, 20% protein) on Day 8. Insulin sensitivity index (SI) was calculated from the minimal model. Results: After controlling for SI, African-Americans have a higher mean apoAI level in HDL with apoCIII compared with whites (12.9 ± 2.8 and 10.9 ± 2.9 mg/dL, respectively, P = 0.05). SI was associated with higher apoAI in HDL with apoCIII, whereas VAT was not associated with this HDL subspecies. This pattern of results was reversed for apoCIII concentrations in apoB lipoproteins. After adjusting for SI, African-Americans had lower apoCIII in apoB lipoproteins. SI was associated with lower apoCIII in total apoB lipoproteins, whereas VAT was associated with higher apoCIII in all the apoB lipoproteins. Additional adjustment for VAT tended to reduce the difference in apoCIII between the groups. Conclusions: African-American women have a higher HDL with apoCIII level than whites when controlled for insulin sensitivity. African-Americans have lower insulin sensitivity. Insulin sensitivity is associated with higher levels of HDL with apoCIII. ApoCIII levels in VLDL are lower in African-American women than whites, also affected by insulin sensitivity which is associated with low apoCIII in VLDL. VAT has a strong association with apoCIII in apoB lipoproteins but not with apoAI in HDL with apoCIII. Trial registration ClinicalTrials.gov Identifier: NCT00484861en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/1743-7075-11-56en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280695/pdf/en
dash.licenseLAAen_US
dc.subjectApoAIen
dc.subjectApoCIIIen
dc.subjectHDLen
dc.subjectApoB lipoproteinsen
dc.subjectVisceral adipose tissueen
dc.subjectInsulin resistanceen
dc.subjectAfrican-Americansen
dc.subjectCoronary heart diseaseen
dc.titleRacial differences between African-American and white women in insulin resistance and visceral adiposity are associated with differences in apoCIII containing apoAI and apoB lipoproteinsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNutrition & Metabolismen
dash.depositing.authorSacks, Frank Men_US
dc.date.available2015-02-02T15:31:51Z
dc.identifier.doi10.1186/1743-7075-11-56*
dash.contributor.affiliatedFurtado, Jeremy
dash.contributor.affiliatedSacks, Frank


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