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dc.contributor.authorBaumert, Jensen_US
dc.contributor.authorHuang, Jieen_US
dc.contributor.authorMcKnight, Barbaraen_US
dc.contributor.authorSabater-Lleal, Mariaen_US
dc.contributor.authorSteri, Maristellaen_US
dc.contributor.authorChu, Audrey Y.en_US
dc.contributor.authorTrompet, Stellaen_US
dc.contributor.authorLopez, Lorna M.en_US
dc.contributor.authorFornage, Myriamen_US
dc.contributor.authorTeumer, Alexanderen_US
dc.contributor.authorTang, Weihongen_US
dc.contributor.authorRudnicka, Alicja R.en_US
dc.contributor.authorMälarstig, Andersen_US
dc.contributor.authorHottenga, Jouke-Janen_US
dc.contributor.authorKavousi, Maryamen_US
dc.contributor.authorLahti, Jarien_US
dc.contributor.authorTanaka, Toshikoen_US
dc.contributor.authorHayward, Carolineen_US
dc.contributor.authorHuffman, Jennifer E.en_US
dc.contributor.authorMorange, Pierre-Emmanuelen_US
dc.contributor.authorRose, Lynda M.en_US
dc.contributor.authorBasu, Saonlien_US
dc.contributor.authorRumley, Annen_US
dc.contributor.authorStott, David J.en_US
dc.contributor.authorBuckley, Brendan M.en_US
dc.contributor.authorde Craen, Anton J. M.en_US
dc.contributor.authorSanna, Serenaen_US
dc.contributor.authorMasala, Marcoen_US
dc.contributor.authorBiffar, Reineren_US
dc.contributor.authorHomuth, Georgen_US
dc.contributor.authorSilveira, Angelaen_US
dc.contributor.authorSennblad, Bengten_US
dc.contributor.authorGoel, Anujen_US
dc.contributor.authorWatkins, Hughen_US
dc.contributor.authorMüller-Nurasyid, Martinaen_US
dc.contributor.authorRückerl, Reginaen_US
dc.contributor.authorTaylor, Kenten_US
dc.contributor.authorChen, Ming-Hueien_US
dc.contributor.authorde Geus, Eco J. C.en_US
dc.contributor.authorHofman, Alberten_US
dc.contributor.authorWitteman, Jacqueline C. M.en_US
dc.contributor.authorde Maat, Moniek P. M.en_US
dc.contributor.authorPalotie, Aarnoen_US
dc.contributor.authorDavies, Gailen_US
dc.contributor.authorSiscovick, David S.en_US
dc.contributor.authorKolcic, Ivanaen_US
dc.contributor.authorWild, Sarah H.en_US
dc.contributor.authorSong, Jaejoonen_US
dc.contributor.authorMcArdle, Wendy L.en_US
dc.contributor.authorFord, Ianen_US
dc.contributor.authorSattar, Naveeden_US
dc.contributor.authorSchlessinger, Daviden_US
dc.contributor.authorGrotevendt, Anneen_US
dc.contributor.authorFranzosi, Maria Graziaen_US
dc.contributor.authorIllig, Thomasen_US
dc.contributor.authorWaldenberger, Melanieen_US
dc.contributor.authorLumley, Thomasen_US
dc.contributor.authorTofler, Geoffrey H.en_US
dc.contributor.authorWillemsen, Gonnekeen_US
dc.contributor.authorUitterlinden, André G.en_US
dc.contributor.authorRivadeneira, Fernandoen_US
dc.contributor.authorRäikkönen, Katrien_US
dc.contributor.authorChasman, Daniel I.en_US
dc.contributor.authorFolsom, Aaron R.en_US
dc.contributor.authorLowe, Gordon D.en_US
dc.contributor.authorWestendorp, Rudi G. J.en_US
dc.contributor.authorSlagboom, P. Elineen_US
dc.contributor.authorCucca, Francescoen_US
dc.contributor.authorWallaschofski, Henrien_US
dc.contributor.authorStrawbridge, Rona J.en_US
dc.contributor.authorSeedorf, Udoen_US
dc.contributor.authorKoenig, Wolfgangen_US
dc.contributor.authorBis, Joshua C.en_US
dc.contributor.authorMukamal, Kenneth J.en_US
dc.contributor.authorvan Dongen, Jennyen_US
dc.contributor.authorWiden, Elisabethen_US
dc.contributor.authorFranco, Oscar H.en_US
dc.contributor.authorStarr, John M.en_US
dc.contributor.authorLiu, Kiangen_US
dc.contributor.authorFerrucci, Luigien_US
dc.contributor.authorPolasek, Ozrenen_US
dc.contributor.authorWilson, James F.en_US
dc.contributor.authorOudot-Mellakh, Tiphaineen_US
dc.contributor.authorCampbell, Harryen_US
dc.contributor.authorNavarro, Pauen_US
dc.contributor.authorBandinelli, Stefaniaen_US
dc.contributor.authorEriksson, Johanen_US
dc.contributor.authorBoomsma, Dorret I.en_US
dc.contributor.authorDehghan, Abbasen_US
dc.contributor.authorClarke, Roberten_US
dc.contributor.authorHamsten, Andersen_US
dc.contributor.authorBoerwinkle, Ericen_US
dc.contributor.authorJukema, J. Wouteren_US
dc.contributor.authorNaitza, Silviaen_US
dc.contributor.authorRidker, Paul M.en_US
dc.contributor.authorVölzke, Henryen_US
dc.contributor.authorDeary, Ian J.en_US
dc.contributor.authorReiner, Alexander P.en_US
dc.contributor.authorTrégouët, David-Alexandreen_US
dc.contributor.authorO'Donnell, Christopher J.en_US
dc.contributor.authorStrachan, David P.en_US
dc.contributor.authorPeters, Annetteen_US
dc.contributor.authorSmith, Nicholas L.en_US
dc.date.accessioned2015-02-02T15:31:51Z
dc.date.issued2014en_US
dc.identifier.citationBaumert, J., J. Huang, B. McKnight, M. Sabater-Lleal, M. Steri, A. Y. Chu, S. Trompet, et al. 2014. “No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects.” PLoS ONE 9 (12): e111156. doi:10.1371/journal.pone.0111156. http://dx.doi.org/10.1371/journal.pone.0111156.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13890619
dc.description.abstractPlasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations. However, little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation. Therefore, we conducted large-scale meta-analyses of genome-wide interaction studies to identify possible interactions of genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentration. The present study included 80,607 subjects of European ancestry from 22 studies. Genome-wide interaction analyses were performed separately in each study for about 2.6 million single nucleotide polymorphisms (SNPs) across the 22 autosomal chromosomes. For each SNP and risk factor, we performed a linear regression under an additive genetic model including an interaction term between SNP and risk factor. Interaction estimates were meta-analysed using a fixed-effects model. No genome-wide significant interaction with smoking status, alcohol consumption or BMI was observed in the meta-analyses. The most suggestive interaction was found for smoking and rs10519203, located in the LOC123688 region on chromosome 15, with a p value of 6.2×10−8. This large genome-wide interaction study including 80,607 participants found no strong evidence of interaction between genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentrations. Further studies are needed to yield deeper insight in the interplay between environmental factors and gene variants on the regulation of fibrinogen concentrations.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0111156en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281156/pdf/en
dash.licenseLAAen_US
dc.subjectMedicine and Health Sciencesen
dc.subjectCardiologyen
dc.subjectClinical Geneticsen
dc.subjectEpidemiologyen
dc.subjectHematologyen
dc.titleNo Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjectsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorChasman, Daniel I.en_US
dc.date.available2015-02-02T15:31:51Z
dc.identifier.doi10.1371/journal.pone.0111156*
dash.authorsorderedfalse
dash.contributor.affiliatedChasman, Daniel
dash.contributor.affiliatedMukamal, Kenneth
dash.contributor.affiliatedRidker, Paul
dc.identifier.orcid0000-0003-1249-4522


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