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dc.contributor.authorRipke, Stephanen_US
dc.contributor.authorNeale, Benjamin Men_US
dc.contributor.authorCorvin, Aidenen_US
dc.contributor.authorWalters, James TRen_US
dc.contributor.authorFarh, Kai-Howen_US
dc.contributor.authorHolmans, Peter Aen_US
dc.contributor.authorLee, Philen_US
dc.contributor.authorBulik-Sullivan, Brendanen_US
dc.contributor.authorCollier, David Aen_US
dc.contributor.authorHuang, Hailiangen_US
dc.contributor.authorPers, Tune Hen_US
dc.contributor.authorAgartz, Ingriden_US
dc.contributor.authorAgerbo, Esbenen_US
dc.contributor.authorAlbus, Margoten_US
dc.contributor.authorAlexander, Madelineen_US
dc.contributor.authorAmin, Farooqen_US
dc.contributor.authorBacanu, Silviu Aen_US
dc.contributor.authorBegemann, Martinen_US
dc.contributor.authorBelliveau, Richard Aen_US
dc.contributor.authorBene, Juditen_US
dc.contributor.authorBergen, Sarah Een_US
dc.contributor.authorBevilacqua, Elizabethen_US
dc.contributor.authorBigdeli, Tim Ben_US
dc.contributor.authorBlack, Donald Wen_US
dc.contributor.authorBruggeman, Richarden_US
dc.contributor.authorBuccola, Nancy Gen_US
dc.contributor.authorBuckner, Randy Len_US
dc.contributor.authorByerley, Williamen_US
dc.contributor.authorCahn, Wiepkeen_US
dc.contributor.authorCai, Guiqingen_US
dc.contributor.authorCampion, Dominiqueen_US
dc.contributor.authorCantor, Rita Men_US
dc.contributor.authorCarr, Vaughan Jen_US
dc.contributor.authorCarrera, Noaen_US
dc.contributor.authorCatts, Stanley Ven_US
dc.contributor.authorChambert, Kimberley Den_US
dc.contributor.authorChan, Raymond CKen_US
dc.contributor.authorChan, Ronald YLen_US
dc.contributor.authorChen, Eric YHen_US
dc.contributor.authorCheng, Weien_US
dc.contributor.authorCheung, Eric FCen_US
dc.contributor.authorChong, Siow Annen_US
dc.contributor.authorCloninger, C Roberten_US
dc.contributor.authorCohen, Daviden_US
dc.contributor.authorCohen, Nadineen_US
dc.contributor.authorCormican, Paulen_US
dc.contributor.authorCraddock, Nicken_US
dc.contributor.authorCrowley, James Jen_US
dc.contributor.authorCurtis, Daviden_US
dc.contributor.authorDavidson, Michaelen_US
dc.contributor.authorDavis, Kenneth Len_US
dc.contributor.authorDegenhardt, Franziskaen_US
dc.contributor.authorDel Favero, Jurgenen_US
dc.contributor.authorDemontis, Ditteen_US
dc.contributor.authorDikeos, Dimitrisen_US
dc.contributor.authorDinan, Timothyen_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorDonohoe, Garyen_US
dc.contributor.authorDrapeau, Elodieen_US
dc.contributor.authorDuan, Jubaoen_US
dc.contributor.authorDudbridge, Franken_US
dc.contributor.authorDurmishi, Naseren_US
dc.contributor.authorEichhammer, Peteren_US
dc.contributor.authorEriksson, Johanen_US
dc.contributor.authorEscott-Price, Valentinaen_US
dc.contributor.authorEssioux, Laurenten_US
dc.contributor.authorFanous, Ayman Hen_US
dc.contributor.authorFarrell, Martilias Sen_US
dc.contributor.authorFrank, Josefen_US
dc.contributor.authorFranke, Ludeen_US
dc.contributor.authorFreedman, Roberten_US
dc.contributor.authorFreimer, Nelson Ben_US
dc.contributor.authorFriedl, Marionen_US
dc.contributor.authorFriedman, Joseph Ien_US
dc.contributor.authorFromer, Menachemen_US
dc.contributor.authorGenovese, Giulioen_US
dc.contributor.authorGeorgieva, Lyudmilaen_US
dc.contributor.authorGiegling, Inaen_US
dc.contributor.authorGiusti-Rodríguez, Paolaen_US
dc.contributor.authorGodard, Stephanieen_US
dc.contributor.authorGoldstein, Jacqueline Ien_US
dc.contributor.authorGolimbet, Veraen_US
dc.contributor.authorGopal, Sriharien_US
dc.contributor.authorGratten, Jacoben_US
dc.contributor.authorde Haan, Lieuween_US
dc.contributor.authorHammer, Christianen_US
dc.contributor.authorHamshere, Marian Len_US
dc.contributor.authorHansen, Marken_US
dc.contributor.authorHansen, Thomasen_US
dc.contributor.authorHaroutunian, Vahramen_US
dc.contributor.authorHartmann, Annette Men_US
dc.contributor.authorHenskens, Frans Aen_US
dc.contributor.authorHerms, Stefanen_US
dc.contributor.authorHirschhorn, Joel Nen_US
dc.contributor.authorHoffmann, Peren_US
dc.contributor.authorHofman, Andreaen_US
dc.contributor.authorHollegaard, Mads Ven_US
dc.contributor.authorHougaard, David Men_US
dc.contributor.authorIkeda, Masashien_US
dc.contributor.authorJoa, Ingeen_US
dc.contributor.authorJulià, Antonioen_US
dc.contributor.authorKahn, René Sen_US
dc.contributor.authorKalaydjieva, Lubaen_US
dc.contributor.authorKarachanak-Yankova, Senaen_US
dc.contributor.authorKarjalainen, Juhaen_US
dc.contributor.authorKavanagh, Daviden_US
dc.contributor.authorKeller, Matthew Cen_US
dc.contributor.authorKennedy, James Len_US
dc.contributor.authorKhrunin, Andreyen_US
dc.contributor.authorKim, Yunjungen_US
dc.contributor.authorKlovins, Janisen_US
dc.contributor.authorKnowles, James Aen_US
dc.contributor.authorKonte, Bettinaen_US
dc.contributor.authorKucinskas, Vaidutisen_US
dc.contributor.authorKucinskiene, Zita Ausreleen_US
dc.contributor.authorKuzelova-Ptackova, Hanaen_US
dc.contributor.authorKähler, Anna Ken_US
dc.contributor.authorLaurent, Claudineen_US
dc.contributor.authorLee, Jimmyen_US
dc.contributor.authorLee, S Hongen_US
dc.contributor.authorLegge, Sophie Een_US
dc.contributor.authorLerer, Bernarden_US
dc.contributor.authorLi, Miaoxinen_US
dc.contributor.authorLi, Taoen_US
dc.contributor.authorLiang, Kung-Yeeen_US
dc.contributor.authorLieberman, Jeffreyen_US
dc.contributor.authorLimborska, Svetlanaen_US
dc.contributor.authorLoughland, Carmel Men_US
dc.contributor.authorLubinski, Janen_US
dc.contributor.authorLönnqvist, Joukoen_US
dc.contributor.authorMacek, Milanen_US
dc.contributor.authorMagnusson, Patrik KEen_US
dc.contributor.authorMaher, Brion Sen_US
dc.contributor.authorMaier, Wolfgangen_US
dc.contributor.authorMallet, Jacquesen_US
dc.contributor.authorMarsal, Saraen_US
dc.contributor.authorMattheisen, Manuelen_US
dc.contributor.authorMattingsdal, Mortenen_US
dc.contributor.authorMcCarley, Robert Wen_US
dc.contributor.authorMcDonald, Colmen_US
dc.contributor.authorMcIntosh, Andrew Men_US
dc.contributor.authorMeier, Sandraen_US
dc.contributor.authorMeijer, Carin Jen_US
dc.contributor.authorMelegh, Belaen_US
dc.contributor.authorMelle, Ingriden_US
dc.contributor.authorMesholam-Gately, Raquelle Ien_US
dc.contributor.authorMetspalu, Andresen_US
dc.contributor.authorMichie, Patricia Ten_US
dc.contributor.authorMilani, Lilien_US
dc.contributor.authorMilanova, Vihraen_US
dc.contributor.authorMokrab, Younesen_US
dc.contributor.authorMorris, Derek Wen_US
dc.contributor.authorMors, Oleen_US
dc.contributor.authorMurphy, Kieran Cen_US
dc.contributor.authorMurray, Robin Men_US
dc.contributor.authorMyin-Germeys, Inezen_US
dc.contributor.authorMüller-Myhsok, Bertramen_US
dc.contributor.authorNelis, Marien_US
dc.contributor.authorNenadic, Igoren_US
dc.contributor.authorNertney, Deborah Aen_US
dc.contributor.authorNestadt, Geralden_US
dc.contributor.authorNicodemus, Kristin Ken_US
dc.contributor.authorNikitina-Zake, Lieneen_US
dc.contributor.authorNisenbaum, Lauraen_US
dc.contributor.authorNordin, Annelieen_US
dc.contributor.authorO’Callaghan, Eadbharden_US
dc.contributor.authorO’Dushlaine, Colmen_US
dc.contributor.authorO’Neill, F Anthonyen_US
dc.contributor.authorOh, Sang-Yunen_US
dc.contributor.authorOlincy, Annen_US
dc.contributor.authorOlsen, Lineen_US
dc.contributor.authorVan Os, Jimen_US
dc.contributor.authorPantelis, Christosen_US
dc.contributor.authorPapadimitriou, George Nen_US
dc.contributor.authorPapiol, Sergien_US
dc.contributor.authorParkhomenko, Elenaen_US
dc.contributor.authorPato, Michele Ten_US
dc.contributor.authorPaunio, Tiinaen_US
dc.contributor.authorPejovic-Milovancevic, Milicaen_US
dc.contributor.authorPerkins, Diana Oen_US
dc.contributor.authorPietiläinen, Ollien_US
dc.contributor.authorPimm, Jonathanen_US
dc.contributor.authorPocklington, Andrew Jen_US
dc.contributor.authorPowell, Johnen_US
dc.contributor.authorPrice, Alkesen_US
dc.contributor.authorPulver, Ann Een_US
dc.contributor.authorPurcell, Shaun Men_US
dc.contributor.authorQuested, Digbyen_US
dc.contributor.authorRasmussen, Henrik Ben_US
dc.contributor.authorReichenberg, Abrahamen_US
dc.contributor.authorReimers, Mark Aen_US
dc.contributor.authorRichards, Alexander Len_US
dc.contributor.authorRoffman, Joshua Len_US
dc.contributor.authorRoussos, Panosen_US
dc.contributor.authorRuderfer, Douglas Men_US
dc.contributor.authorSalomaa, Veikkoen_US
dc.contributor.authorSanders, Alan Ren_US
dc.contributor.authorSchall, Ulrichen_US
dc.contributor.authorSchubert, Christian Ren_US
dc.contributor.authorSchulze, Thomas Gen_US
dc.contributor.authorSchwab, Sibylle Gen_US
dc.contributor.authorScolnick, Edward Men_US
dc.contributor.authorScott, Rodney Jen_US
dc.contributor.authorSeidman, Larry Jen_US
dc.contributor.authorShi, Jianxinen_US
dc.contributor.authorSigurdsson, Engilberten_US
dc.contributor.authorSilagadze, Teimurazen_US
dc.contributor.authorSilverman, Jeremy Men_US
dc.contributor.authorSim, Kangen_US
dc.contributor.authorSlominsky, Petren_US
dc.contributor.authorSmoller, Jordan Wen_US
dc.contributor.authorSo, Hon-Cheongen_US
dc.contributor.authorSpencer, Chris C Aen_US
dc.contributor.authorStahl, Eli Aen_US
dc.contributor.authorStefansson, Hreinnen_US
dc.contributor.authorSteinberg, Stacyen_US
dc.contributor.authorStogmann, Elisabethen_US
dc.contributor.authorStraub, Richard Een_US
dc.contributor.authorStrengman, Ericen_US
dc.contributor.authorStrohmaier, Janaen_US
dc.contributor.authorStroup, T Scotten_US
dc.contributor.authorSubramaniam, Mythilyen_US
dc.contributor.authorSuvisaari, Jaanaen_US
dc.contributor.authorSvrakic, Dragan Men_US
dc.contributor.authorSzatkiewicz, Jin Pen_US
dc.contributor.authorSöderman, Eriken_US
dc.contributor.authorThirumalai, Srinivasen_US
dc.contributor.authorToncheva, Dragaen_US
dc.contributor.authorTosato, Sarahen_US
dc.contributor.authorVeijola, Juhaen_US
dc.contributor.authorWaddington, Johnen_US
dc.contributor.authorWalsh, Dermoten_US
dc.contributor.authorWang, Daien_US
dc.contributor.authorWang, Qiangen_US
dc.contributor.authorWebb, Bradley Ten_US
dc.contributor.authorWeiser, Marken_US
dc.contributor.authorWildenauer, Dieter Ben_US
dc.contributor.authorWilliams, Nigel Men_US
dc.contributor.authorWilliams, Stephanieen_US
dc.contributor.authorWitt, Stephanie Hen_US
dc.contributor.authorWolen, Aaron Ren_US
dc.contributor.authorWong, Emily HMen_US
dc.contributor.authorWormley, Brandon Ken_US
dc.contributor.authorXi, Hualin Simonen_US
dc.contributor.authorZai, Clement Cen_US
dc.contributor.authorZheng, Xuebinen_US
dc.contributor.authorZimprich, Fritzen_US
dc.contributor.authorWray, Naomi Ren_US
dc.contributor.authorStefansson, Karien_US
dc.contributor.authorVisscher, Peter Men_US
dc.contributor.authorAdolfsson, Rolfen_US
dc.contributor.authorAndreassen, Ole Aen_US
dc.contributor.authorBlackwood, Douglas HRen_US
dc.contributor.authorBramon, Elviraen_US
dc.contributor.authorBuxbaum, Joseph Den_US
dc.contributor.authorBørglum, Anders Den_US
dc.contributor.authorCichon, Svenen_US
dc.contributor.authorDarvasi, Arielen_US
dc.contributor.authorDomenici, Enricoen_US
dc.contributor.authorEhrenreich, Hanneloreen_US
dc.contributor.authorEsko, Tõnuen_US
dc.contributor.authorGejman, Pablo Ven_US
dc.contributor.authorGill, Michaelen_US
dc.contributor.authorGurling, Hughen_US
dc.contributor.authorHultman, Christina Men_US
dc.contributor.authorIwata, Nakaoen_US
dc.contributor.authorJablensky, Assen Ven_US
dc.contributor.authorJönsson, Erik Gen_US
dc.contributor.authorKendler, Kenneth Sen_US
dc.contributor.authorKirov, Georgeen_US
dc.contributor.authorKnight, Joen_US
dc.contributor.authorLencz, Todden_US
dc.contributor.authorLevinson, Douglas Fen_US
dc.contributor.authorLi, Qingqin Sen_US
dc.contributor.authorLiu, Jianjunen_US
dc.contributor.authorMalhotra, Anil Ken_US
dc.contributor.authorMcCarroll, Steven Aen_US
dc.contributor.authorMcQuillin, Andrewen_US
dc.contributor.authorMoran, Jennifer Len_US
dc.contributor.authorMortensen, Preben Ben_US
dc.contributor.authorMowry, Bryan Jen_US
dc.contributor.authorNöthen, Markus Men_US
dc.contributor.authorOphoff, Roel Aen_US
dc.contributor.authorOwen, Michael Jen_US
dc.contributor.authorPalotie, Aarnoen_US
dc.contributor.authorPato, Carlos Nen_US
dc.contributor.authorPetryshen, Tracey Len_US
dc.contributor.authorPosthuma, Danielleen_US
dc.contributor.authorRietschel, Marcellaen_US
dc.contributor.authorRiley, Brien Pen_US
dc.contributor.authorRujescu, Danen_US
dc.contributor.authorSham, Pak Cen_US
dc.contributor.authorSklar, Pamelaen_US
dc.contributor.authorSt Clair, Daviden_US
dc.contributor.authorWeinberger, Daniel Ren_US
dc.contributor.authorWendland, Jens Ren_US
dc.contributor.authorWerge, Thomasen_US
dc.contributor.authorDaly, Mark Jen_US
dc.contributor.authorSullivan, Patrick Fen_US
dc.contributor.authorO’Donovan, Michael Cen_US
dc.date.accessioned2015-02-02T15:32:11Z
dc.date.issued2014en_US
dc.identifier.citationRipke, S., B. M. Neale, A. Corvin, J. T. Walters, K. Farh, P. A. Holmans, P. Lee, et al. 2014. “Biological Insights From 108 Schizophrenia-Associated Genetic Loci.” Nature 511 (7510): 421-427. doi:10.1038/nature13595. http://dx.doi.org/10.1038/nature13595.en
dc.identifier.issn0028-0836en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13890642
dc.description.abstractSummary Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here, we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain providing biological plausibility for the findings. Many findings have the potential to provide entirely novel insights into aetiology, but associations at DRD2 and multiple genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that play important roles in immunity, providing support for the hypothesized link between the immune system and schizophrenia.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/nature13595en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112379/pdf/en
dash.licenseLAAen_US
dc.titleBiological Insights From 108 Schizophrenia-Associated Genetic Locien
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNatureen
dash.depositing.authorRipke, Stephanen_US
dc.date.available2015-02-02T15:32:11Z
dc.identifier.doi10.1038/nature13595*
dash.authorsorderedfalse
dash.contributor.affiliatedFarh, Kai-How
dash.contributor.affiliatedLee, Phil
dash.contributor.affiliatedNeale, Benjamin
dash.contributor.affiliatedHuang, Hailiang
dash.contributor.affiliatedRipke, Stephan
dash.contributor.affiliatedBuckner, Randy
dash.contributor.affiliatedPers, Tune H
dash.contributor.affiliatedHirschhorn, Joel
dash.contributor.affiliatedMesholam-Gately, Raquelle
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedRoffman, Joshua
dash.contributor.affiliatedPrice, Alkes
dash.contributor.affiliatedScolnick, Edward
dash.contributor.affiliatedSmoller, Jordan
dash.contributor.affiliatedSeidman, Larry Joel
dash.contributor.affiliatedPetryshen, Tracey L.
dash.contributor.affiliatedEsko, Tõnu
dash.contributor.affiliatedMcCarroll, Steven
dash.contributor.affiliatedPalotie, Aarno
dash.contributor.affiliatedDaly, Mark


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