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dc.contributor.authorGarst-Orozco, Jonathanen_US
dc.contributor.authorBabadi, Baktashen_US
dc.contributor.authorÖlveczky, Bence Pen_US
dc.date.accessioned2015-02-02T15:32:23Z
dc.date.issued2014en_US
dc.identifier.citationGarst-Orozco, Jonathan, Baktash Babadi, and Bence P Ölveczky. 2014. “A neural circuit mechanism for regulating vocal variability during song learning in zebra finches.” eLife 3 (1): e03697. doi:10.7554/eLife.03697. http://dx.doi.org/10.7554/eLife.03697.en
dc.identifier.issn2050-084Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13890648
dc.description.abstractMotor skill learning is characterized by improved performance and reduced motor variability. The neural mechanisms that couple skill level and variability, however, are not known. The zebra finch, a songbird, presents a unique opportunity to address this question because production of learned song and induction of vocal variability are instantiated in distinct circuits that converge on a motor cortex analogue controlling vocal output. To probe the interplay between learning and variability, we made intracellular recordings from neurons in this area, characterizing how their inputs from the functionally distinct pathways change throughout song development. We found that inputs that drive stereotyped song-patterns are strengthened and pruned, while inputs that induce variability remain unchanged. A simple network model showed that strengthening and pruning of action-specific connections reduces the sensitivity of motor control circuits to variable input and neural ‘noise’. This identifies a simple and general mechanism for learning-related regulation of motor variability. DOI: http://dx.doi.org/10.7554/eLife.03697.001en
dc.language.isoen_USen
dc.publishereLife Sciences Publications, Ltden
dc.relation.isversionofdoi:10.7554/eLife.03697en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290448/pdf/en
dash.licenseLAAen_US
dc.subjectsongbirden
dc.subjectmotor learningen
dc.subjectmotor variabilityen
dc.subjectreinforcement learningen
dc.subjectmotor controlen
dc.subjectsynaptic plasticityen
dc.subjectotheren
dc.titleA neural circuit mechanism for regulating vocal variability during song learning in zebra finchesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journaleLifeen
dash.depositing.authorÖlveczky, Bence Pen_US
dc.date.available2015-02-02T15:32:23Z
dc.identifier.doi10.7554/eLife.03697*
dash.contributor.affiliatedOlveczky, Bence


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