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dc.contributor.authorNagy, Stanislaven_US
dc.contributor.authorTramm, Noraen_US
dc.contributor.authorSanders, Jarreden_US
dc.contributor.authorIwanir, Shacharen_US
dc.contributor.authorShirley, Ian Aen_US
dc.contributor.authorLevine, Erelen_US
dc.contributor.authorBiron, Daviden_US
dc.date.accessioned2015-02-02T15:32:31Z
dc.date.issued2014en_US
dc.identifier.citationNagy, Stanislav, Nora Tramm, Jarred Sanders, Shachar Iwanir, Ian A Shirley, Erel Levine, and David Biron. 2014. “Homeostasis in C. elegans sleep is characterized by two behaviorally and genetically distinct mechanisms.” eLife 3 (1): e04380. doi:10.7554/eLife.04380. http://dx.doi.org/10.7554/eLife.04380.en
dc.identifier.issn2050-084Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13890664
dc.description.abstractBiological homeostasis invokes modulatory responses aimed at stabilizing internal conditions. Using tunable photo- and mechano-stimulation, we identified two distinct categories of homeostatic responses during the sleep-like state of Caenorhabditis elegans (lethargus). In the presence of weak or no stimuli, extended motion caused a subsequent extension of quiescence. The neuropeptide Y receptor homolog, NPR-1, and an inhibitory neuropeptide known to activate it, FLP-18, were required for this process. In the presence of strong stimuli, the correlations between motion and quiescence were disrupted for several minutes but homeostasis manifested as an overall elevation of the time spent in quiescence. This response to strong stimuli required the function of the DAF-16/FOXO transcription factor in neurons, but not that of NPR-1. Conversely, response to weak stimuli did not require the function of DAF-16/FOXO. These findings suggest that routine homeostatic stabilization of sleep may be distinct from homeostatic compensation following a strong disturbance. DOI: http://dx.doi.org/10.7554/eLife.04380.001en
dc.language.isoen_USen
dc.publishereLife Sciences Publications, Ltden
dc.relation.isversionofdoi:10.7554/eLife.04380en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273442/pdf/en
dash.licenseLAAen_US
dc.subjectsleepen
dc.subjecthomeostasisen
dc.subjectlethargusen
dc.subjectquiescenceen
dc.subjectneuropeptidesen
dc.subjectinsulinen
dc.subjecten
dc.titleHomeostasis in C. elegans sleep is characterized by two behaviorally and genetically distinct mechanismsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journaleLifeen
dash.depositing.authorLevine, Erelen_US
dc.date.available2015-02-02T15:32:31Z
dc.identifier.doi10.7554/eLife.04380*
dash.contributor.affiliatedLevine, Erel


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