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dc.contributor.authorNapadow, Vitalyen_US
dc.contributor.authorHarris, Richard Een_US
dc.date.accessioned2015-02-02T15:32:49Z
dc.date.issued2014en_US
dc.identifier.citationNapadow, Vitaly, and Richard E Harris. 2014. “What has functional connectivity and chemical neuroimaging in fibromyalgia taught us about the mechanisms and management of ‘centralized’ pain?” Arthritis Research & Therapy 16 (4): 425. doi:10.1186/s13075-014-0425-0. http://dx.doi.org/10.1186/s13075-014-0425-0.en
dc.identifier.issn1478-6354en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13890690
dc.description.abstractResearch suggests that fibromyalgia is a central, widespread pain syndrome supported by a generalized disturbance in central nervous system pain processing. Over the past decades, multiple lines of research have identified the locus for many functional, chronic pain disorders to the central nervous system, and the brain. In recent years, brain neuroimaging techniques have heralded a revolution in our understanding of chronic pain, as they have allowed researchers to non-invasively (or minimally invasively) evaluate human patients suffering from various pain disorders. While many neuroimaging techniques have been developed, growing interest in two specific imaging modalities has led to significant contributions to chronic pain research. For instance, resting functional connectivity magnetic resonance imaging (fcMRI) is a recent adaptation of fMRI that examines intrinsic brain connectivity - defined as synchronous oscillations of the fMRI signal that occurs in the resting basal state. Proton magnetic resonance spectroscopy (1H-MRS) is a non-invasive magnetic resonance imaging technique that can quantify the concentration of multiple metabolites within the human brain. This review will outline recent applications of the complementary imaging techniques - fcMRI and 1H-MRS - to improve our understanding of fibromyalgia pathophysiology and how pharmacological and non-pharmacological therapies contribute to analgesia in these patients. A better understanding of the brain in chronic pain, with specific linkage as to which neural processes relate to spontaneous pain perception and hyperalgesia, will greatly improve our ability to develop novel therapeutics. Neuroimaging will play a growing role in the translational research approaches needed to make this a reality.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/s13075-014-0425-0en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289059/pdf/en
dash.licenseLAAen_US
dc.titleWhat has functional connectivity and chemical neuroimaging in fibromyalgia taught us about the mechanisms and management of ‘centralized’ pain?en
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalArthritis Research & Therapyen
dash.depositing.authorNapadow, Vitalyen_US
dc.date.available2015-02-02T15:32:49Z
dc.identifier.doi10.1186/s13075-014-0425-0*
dash.contributor.affiliatedNapadow, Vitaly


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