Pancreas-Targeted NIR Fluorophores for Dual-Channel Image-Guided Abdominal Surgery

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Pancreas-Targeted NIR Fluorophores for Dual-Channel Image-Guided Abdominal Surgery

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Title: Pancreas-Targeted NIR Fluorophores for Dual-Channel Image-Guided Abdominal Surgery
Author: Wada, Hideyuki; Hyun, Hoon; Vargas, Christina; Gravier, Julien; Park, GwangLi; Gioux, Sylvain; Frangioni, John V.; Henary, Maged; Choi, Hak Soo

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Citation: Wada, Hideyuki, Hoon Hyun, Christina Vargas, Julien Gravier, GwangLi Park, Sylvain Gioux, John V. Frangioni, Maged Henary, and Hak Soo Choi. 2015. “Pancreas-Targeted NIR Fluorophores for Dual-Channel Image-Guided Abdominal Surgery.” Theranostics 5 (1): 1-11. doi:10.7150/thno.10259.
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Abstract: Objective: Pancreas-related complications are some of the most serious ones in abdominal surgery. The goal of this study was to develop and validate novel near-infrared (NIR) fluorophores that would enable real-time pancreas imaging to avoid the intraoperative pancreatic injury. Design: After initial screening of a large NIR fluorophore library, the performance of 3 selected pancreas-targeted 700 nm NIR fluorophores, T700-H, T700-F, and MB, were quantified in mice, rats, and pigs. Dose ranging using 25 and 100 nmol, and 2.5 µmol of T700-F, and its imaging kinetics over a 4 h period were tested in each species. Three different 800 nm NIR fluorophores were employed for dual-channel FLARE™ imaging in pigs: 2 μmol of ZW800-1 for vessels and kidney, 1 μmol of ZW800-3C for lymph nodes, and 2 μmol of ESNF31 for adrenal glands. Results: T700-F demonstrated the highest signal to background ratio (SBR), with peak SBR at 4 h postinjection in mice. In pigs, T700-F produced an SBR ≥ 2 against muscle, spleen, and lymph nodes for up to 8 h after a single intravenous injection. The combination of T700-F with each 800 nm NIR fluorophore provided simultaneous dual-channel intraoperative imaging of pancreas with surrounding organs in real time. Conclusion: Pancreas-targeted NIR fluorophores combined with the FLARE dual-channel imaging system enable the real-time intraoperative pancreas imaging which helps surgeons perform safer and more curative abdominal surgeries.
Published Version: doi:10.7150/thno.10259
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