Primary Immune Deficiencies – Principles of Care

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Author
Chapel, Helen
Prevot, Johan
Gaspar, Hubert Bobby
Español, Teresa
Solis, Leire
Drabwell, Josina
Published Version
https://doi.org/10.3389/fimmu.2014.00627Metadata
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Chapel, Helen, Johan Prevot, Hubert Bobby Gaspar, Teresa Español, Francisco A. Bonilla, Leire Solis, and Josina Drabwell. 2014. “Primary Immune Deficiencies – Principles of Care.” Frontiers in Immunology 5 (1): 627. doi:10.3389/fimmu.2014.00627. http://dx.doi.org/10.3389/fimmu.2014.00627.Abstract
Primary immune deficiencies (PIDs) are a growing group of over 230 different disorders caused by ineffective, absent or an increasing number of gain of function mutations in immune components, mainly cells and proteins. Once recognized, these rare disorders are treatable and in some cases curable. Otherwise untreated PIDs are often chronic, serious, or even fatal. The diagnosis of PIDs can be difficult due to lack of awareness or facilities for diagnosis, and management of PIDs is complex. This document was prepared by a worldwide multi-disciplinary team of specialists; it aims to set out comprehensive principles of care for PIDs. These include the role of specialized centers, the importance of registries, the need for multinational research, the role of patient organizations, management and treatment options, the requirement for sustained access to all treatments including immunoglobulin therapies and hematopoietic stem cell transplantation, important considerations for developing countries and suggestions for implementation. A range of healthcare policies and services have to be put into place by government agencies and healthcare providers, to ensure that PID patients worldwide have access to appropriate and sustainable medical and support services.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266088/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:13890766
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