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dc.contributor.authorChapel, Helenen_US
dc.contributor.authorPrevot, Johanen_US
dc.contributor.authorGaspar, Hubert Bobbyen_US
dc.contributor.authorEspañol, Teresaen_US
dc.contributor.authorBonilla, Francisco A.en_US
dc.contributor.authorSolis, Leireen_US
dc.contributor.authorDrabwell, Josinaen_US
dc.date.accessioned2015-02-02T15:33:19Z
dc.date.issued2014en_US
dc.identifier.citationChapel, Helen, Johan Prevot, Hubert Bobby Gaspar, Teresa Español, Francisco A. Bonilla, Leire Solis, and Josina Drabwell. 2014. “Primary Immune Deficiencies – Principles of Care.” Frontiers in Immunology 5 (1): 627. doi:10.3389/fimmu.2014.00627. http://dx.doi.org/10.3389/fimmu.2014.00627.en
dc.identifier.issn1664-3224en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13890766
dc.description.abstractPrimary immune deficiencies (PIDs) are a growing group of over 230 different disorders caused by ineffective, absent or an increasing number of gain of function mutations in immune components, mainly cells and proteins. Once recognized, these rare disorders are treatable and in some cases curable. Otherwise untreated PIDs are often chronic, serious, or even fatal. The diagnosis of PIDs can be difficult due to lack of awareness or facilities for diagnosis, and management of PIDs is complex. This document was prepared by a worldwide multi-disciplinary team of specialists; it aims to set out comprehensive principles of care for PIDs. These include the role of specialized centers, the importance of registries, the need for multinational research, the role of patient organizations, management and treatment options, the requirement for sustained access to all treatments including immunoglobulin therapies and hematopoietic stem cell transplantation, important considerations for developing countries and suggestions for implementation. A range of healthcare policies and services have to be put into place by government agencies and healthcare providers, to ensure that PID patients worldwide have access to appropriate and sustainable medical and support services.en
dc.language.isoen_USen
dc.publisherFrontiers Media S.A.en
dc.relation.isversionofdoi:10.3389/fimmu.2014.00627en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266088/pdf/en
dash.licenseLAAen_US
dc.subjectHypothesis and Theoryen
dc.subjectprimary immunodeficienciesen
dc.subjectawarenessen
dc.subjectdiagnosisen
dc.subjectmanagementen
dc.subjecttreatmentsen
dc.subjectworldwideen
dc.titlePrimary Immune Deficiencies – Principles of Careen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalFrontiers in Immunologyen
dash.depositing.authorBonilla, Francisco A.en_US
dc.date.available2015-02-02T15:33:19Z
dc.identifier.doi10.3389/fimmu.2014.00627*
dash.contributor.affiliatedBonilla, Francisco


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