MicroRNAs Regulate Vascular Medial Calcification

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MicroRNAs Regulate Vascular Medial Calcification

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Title: MicroRNAs Regulate Vascular Medial Calcification
Author: Leopold, Jane A.
Citation: Leopold, Jane A. 2014. “MicroRNAs Regulate Vascular Medial Calcification.” Cells 3 (4): 963-980. doi:10.3390/cells3040963. http://dx.doi.org/10.3390/cells3040963.
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Abstract: Vascular calcification is highly prevalent in patients with coronary artery disease and, when present, is associated with major adverse cardiovascular events, including an increased risk of cardiovascular mortality. The pathogenesis of vascular calcification is complex and is now recognized to recapitulate skeletal bone formation. Vascular smooth muscle cells (SMC) play an integral role in this process by undergoing transdifferentiation to osteoblast-like cells, elaborating calcifying matrix vesicles and secreting factors that diminish the activity of osteoclast-like cells with mineral resorbing capacity. Recent advances have identified microRNAs (miRs) as key regulators of this process by directing the complex genetic reprogramming of SMCs and the functional responses of other relevant cell types relevant for vascular calcification. This review will detail SMC and bone biology as it relates to vascular calcification and relate what is known to date regarding the regulatory role of miRs in SMC-mediated vascular calcification.
Published Version: doi:10.3390/cells3040963
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276909/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:13890779
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