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dc.contributor.authorSuerth, Julia D.en_US
dc.contributor.authorLabenski, Verenaen_US
dc.contributor.authorSchambach, Axelen_US
dc.date.accessioned2015-02-02T15:33:24Z
dc.date.issued2014en_US
dc.identifier.citationSuerth, Julia D., Verena Labenski, and Axel Schambach. 2014. “Alpharetroviral Vectors: From a Cancer-Causing Agent to a Useful Tool for Human Gene Therapy.” Viruses 6 (12): 4811-4838. doi:10.3390/v6124811. http://dx.doi.org/10.3390/v6124811.en
dc.identifier.issn1999-4915en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13890780
dc.description.abstractGene therapy using integrating retroviral vectors has proven its effectiveness in several clinical trials for the treatment of inherited diseases and cancer. However, vector-mediated adverse events related to insertional mutagenesis were also observed, emphasizing the need for safer therapeutic vectors. Paradoxically, alpharetroviruses, originally discovered as cancer-causing agents, have a more random and potentially safer integration pattern compared to gammaretro- and lentiviruses. In this review, we provide a short overview of the history of alpharetroviruses and explain how they can be converted into state-of-the-art gene delivery tools with improved safety features. We discuss development of alpharetroviral vectors in compliance with regulatory requirements for clinical translation, and provide an outlook on possible future gene therapy applications. Taken together, this review is a broad overview of alpharetroviral vectors spanning the bridge from their parental virus discovery to their potential applicability in clinical settings.en
dc.language.isoen_USen
dc.publisherMDPIen
dc.relation.isversionofdoi:10.3390/v6124811en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276931/pdf/en
dash.licenseLAAen_US
dc.subjectretrovirologyen
dc.subjectalpharetroviral vectoren
dc.subjectgene therapyen
dc.subjectclinical translationen
dc.subjectregulatory requirementsen
dc.subjectvector safetyen
dc.titleAlpharetroviral Vectors: From a Cancer-Causing Agent to a Useful Tool for Human Gene Therapyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalVirusesen
dc.date.available2015-02-02T15:33:24Z
dc.identifier.doi10.3390/v6124811*


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