Plasma-type gelsolin in subarachnoid hemorrhage: novel biomarker today, therapeutic target tomorrow?

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Plasma-type gelsolin in subarachnoid hemorrhage: novel biomarker today, therapeutic target tomorrow?

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dc.contributor.author Chou, Sherry Hsiang-Yi en_US
dc.contributor.author Lo, Eng H en_US
dc.contributor.author Ning, MingMing en_US
dc.date.accessioned 2015-02-02T15:33:27Z
dc.date.issued 2014 en_US
dc.identifier.citation Chou, Sherry Hsiang-Yi, Eng H Lo, and MingMing Ning. 2014. “Plasma-type gelsolin in subarachnoid hemorrhage: novel biomarker today, therapeutic target tomorrow?” Critical Care 18 (1): 101. doi:10.1186/cc13178. http://dx.doi.org/10.1186/cc13178. en
dc.identifier.issn 1364-8535 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:13890788
dc.description.abstract There is growing interest in the potential neuroprotective properties of gelsolin. In particular, plasma-type gelsolin (pGSN) can ameliorate deleterious inflammatory response by scavenging pro-inflammatory signals such as actin and lipopolysaccharide. In a recent issue of Critical Care, Pan and colleagues report an important association between pGSN and subarachnoid hemorrhage (SAH) disease severity, and found pGSN to be a novel and promising biomarker for SAH clinical outcome. Previous research shows pGSN may be actively degraded by neurovascular proteases such as matrix metalloproteinases in the cerebral spinal fluid of SAH patients. Taken together, these results suggest that pGSN is not only a novel marker of SAH clinical outcome, but may also play an active mechanistic role in SAH, and potentially serve as a future therapeutic target. en
dc.language.iso en_US en
dc.publisher BioMed Central en
dc.relation.isversionof doi:10.1186/cc13178 en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056622/pdf/ en
dash.license LAA en_US
dc.title Plasma-type gelsolin in subarachnoid hemorrhage: novel biomarker today, therapeutic target tomorrow? en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal Critical Care en
dash.depositing.author Chou, Sherry Hsiang-Yi en_US
dc.date.available 2015-02-02T15:33:27Z

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