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dc.contributor.authorChou, Sherry Hsiang-Yien_US
dc.contributor.authorLo, Eng Hen_US
dc.contributor.authorNing, MingMingen_US
dc.date.accessioned2015-02-02T15:33:27Z
dc.date.issued2014en_US
dc.identifier.citationChou, Sherry Hsiang-Yi, Eng H Lo, and MingMing Ning. 2014. “Plasma-type gelsolin in subarachnoid hemorrhage: novel biomarker today, therapeutic target tomorrow?” Critical Care 18 (1): 101. doi:10.1186/cc13178. http://dx.doi.org/10.1186/cc13178.en
dc.identifier.issn1364-8535en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13890788
dc.description.abstractThere is growing interest in the potential neuroprotective properties of gelsolin. In particular, plasma-type gelsolin (pGSN) can ameliorate deleterious inflammatory response by scavenging pro-inflammatory signals such as actin and lipopolysaccharide. In a recent issue of Critical Care, Pan and colleagues report an important association between pGSN and subarachnoid hemorrhage (SAH) disease severity, and found pGSN to be a novel and promising biomarker for SAH clinical outcome. Previous research shows pGSN may be actively degraded by neurovascular proteases such as matrix metalloproteinases in the cerebral spinal fluid of SAH patients. Taken together, these results suggest that pGSN is not only a novel marker of SAH clinical outcome, but may also play an active mechanistic role in SAH, and potentially serve as a future therapeutic target.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/cc13178en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056622/pdf/en
dash.licenseLAAen_US
dc.titlePlasma-type gelsolin in subarachnoid hemorrhage: novel biomarker today, therapeutic target tomorrow?en
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalCritical Careen
dash.depositing.authorChou, Sherry Hsiang-Yien_US
dc.date.available2015-02-02T15:33:27Z
dc.identifier.doi10.1186/cc13178*
dash.contributor.affiliatedChou, Sherry Hsiang-Yi
dash.contributor.affiliatedNing, MingMing
dash.contributor.affiliatedLo, Eng


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