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dc.contributor.authorAbedalthagafi, Malak S.en_US
dc.contributor.authorMerrill, Parker H.en_US
dc.contributor.authorBi, Wenya Lindaen_US
dc.contributor.authorJones, Robert T.en_US
dc.contributor.authorListewnik, Marc L.en_US
dc.contributor.authorRamkissoon, Shakti H.en_US
dc.contributor.authorThorner, Aaron R.en_US
dc.contributor.authorDunn, Ian F.en_US
dc.contributor.authorBeroukhim, Rameenen_US
dc.contributor.authorAlexander, Brian M.en_US
dc.contributor.authorBrastianos, Priscilla K.en_US
dc.contributor.authorFrancis, Joshua M.en_US
dc.contributor.authorFolkerth, Rebecca D.en_US
dc.contributor.authorLigon, Keith L.en_US
dc.contributor.authorHummelen, Paul Vanen_US
dc.contributor.authorLigon, Azra H.en_US
dc.contributor.authorSantagata, Sandroen_US
dc.date.accessioned2015-02-02T15:33:29Z
dc.date.issued2014en_US
dc.identifier.citationAbedalthagafi, M. S., P. H. Merrill, W. L. Bi, R. T. Jones, M. L. Listewnik, S. H. Ramkissoon, A. R. Thorner, et al. 2014. “Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5.” Oncotarget 5 (21): 10596-10606.en
dc.identifier.issn1949-2553en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13890791
dc.description.abstractMeningiomas are a diverse group of tumors with a broad spectrum of histologic features. There are over 12 variants of meningioma, whose genetic features are just beginning to be described. Angiomatous meningioma is a World Health Organization (WHO) meningioma variant with a predominance of blood vessels. They are uncommon and confirming the histopathologic classification can be challenging. Given a lack of biomarkers that define the angiomatous subtype and limited understanding of the genetic changes underlying its tumorigenesis, we compared the genomic characteristics of angiomatous meningioma to more common meningioma subtypes. While typical grade I meningiomas demonstrate monosomy of chromosome 22 or lack copy number aberrations, 13 of 14 cases of angiomatous meningioma demonstrated a distinct copy number profile – polysomies of at least one chromosome, but often of many, especially in chromosomes 5, 13, and 20. WHO grade II atypical meningiomas with angiomatous features have both polysomies and genetic aberrations characteristic of other atypical meningiomas. Sequencing of over 560 cancer-relevant genes in 16 cases of angiomatous meningioma showed that these tumors lack common mutations found in other variants of meningioma. Our study demonstrates that angiomatous meningiomas have distinct genomic features that may be clinically useful for their diagnosis.en
dc.language.isoen_USen
dc.publisherImpact Journals LLCen
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279396/pdf/en
dash.licenseLAAen_US
dc.subjectmeningiomaen
dc.subjectangiomatousen
dc.subjectpolysomyen
dc.subjectaCGHen
dc.subjectmolecular diagnosticsen
dc.subjectNext Generation Sequencingen
dc.titleAngiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5en
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalOncotargeten
dash.depositing.authorAbedalthagafi, Malak S.en_US
dc.date.available2015-02-02T15:33:29Z
dc.identifier.doi10.18632/oncotarget.2517
dash.authorsorderedfalse
dash.contributor.affiliatedBrastianos, Priscilla
dash.contributor.affiliatedAlexander, Brian
dash.contributor.affiliatedFrancis, Joshua M.
dash.contributor.affiliatedRamkissoon, Shakti H.
dash.contributor.affiliatedLigon, Azra
dash.contributor.affiliatedFolkerth, Rebecca D.
dash.contributor.affiliatedAbedalthagafi, Malak
dash.contributor.affiliatedDunn, Ian
dash.contributor.affiliatedBi, Wenya
dash.contributor.affiliatedSantagata, Sandro
dash.contributor.affiliatedLigon, Keith


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