Epstein–Barr virus latent genes

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Epstein–Barr virus latent genes

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Title: Epstein–Barr virus latent genes
Author: Kang, Myung-Soo; Kieff, Elliott

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Citation: Kang, Myung-Soo, and Elliott Kieff. 2015. “Epstein–Barr virus latent genes.” Experimental & Molecular Medicine 47 (1): e131. doi:10.1038/emm.2014.84. http://dx.doi.org/10.1038/emm.2014.84.
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Abstract: Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many human disorders. The persistence of these viral genomes in all malignant cells, yet with the expression of limited latent genes, is consistent with the notion that EBV latent genes are important for malignant cell growth. While the EBV-encoded nuclear antigen-1 (EBNA-1) and latent membrane protein-2A (LMP-2A) are critical, the EBNA-leader proteins, EBNA-2, EBNA-3A, EBNA-3C and LMP-1, are individually essential for in vitro transformation of primary B cells to lymphoblastoid cell lines. EBV-encoded RNAs and EBNA-3Bs are dispensable. In this review, the roles of EBV latent genes are summarized.
Published Version: doi:10.1038/emm.2014.84
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314583/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:14065311
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