UV signaling pathways within the skin

DSpace/Manakin Repository

UV signaling pathways within the skin

Citable link to this page


Title: UV signaling pathways within the skin
Author: Chen, Hongxiang; Weng, Qing Yu; Fisher, David E.

Note: Order does not necessarily reflect citation order of authors.

Citation: Chen, Hongxiang, Qing Yu Weng, and David E. Fisher. 2014. “UV signaling pathways within the skin.” The Journal of investigative dermatology 134 (8): 2080-2085. doi:10.1038/jid.2014.161. http://dx.doi.org/10.1038/jid.2014.161.
Full Text & Related Files:
Abstract: The effects of UVR on the skin include tanning, carcinogenesis, immunomodulation, and synthesis of vitamin D, among others. Melanocortin 1 receptor polymorphisms correlate with skin pigmentation, UV sensitivity, and skin cancer risk. This article reviews pathways through which UVR induces cutaneous stress and the pigmentation response. Modulators of the UV tanning pathway include sunscreen agents, MC1R activators, adenylate cyclase activators, phosphodiesterase 4D3 inhibitors, T oligos, and MITF regulators such as histone deacetylase (HDAC)-inhibitors. UVR, as one of the most ubiquitous carcinogens, represents both a challenge and enormous opportunity in skin cancer prevention.
Published Version: doi:10.1038/jid.2014.161
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102648/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:14065313
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search