Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

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Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

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Title: Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A
Author: Wang, Hansong; Burnett, Terrilea; Kono, Suminori; Haiman, Christopher A.; Iwasaki, Motoki; Wilkens, Lynne R.; Loo, Lenora W.M.; Berg, David Van Den; Kolonel, Laurence N.; Henderson, Brian E.; Keku, Temitope O.; Sandler, Robert S.; Signorello, Lisa B.; Blot, William J.; Newcomb, Polly A.; Pande, Mala; Amos, Christopher I.; West, Dee W.; Bézieau, Stéphane; Berndt, Sonja I.; Zanke, Brent W.; Hsu, Li; Lindor, Noralane M.; Haile, Robert W.; Hopper, John L.; Jenkins, Mark A.; Gallinger, Steven; Casey, Graham; Stenzel, Stephanie L.; Schumacher, Fredrick R.; Peters, Ulrike; Gruber, Stephen B.; Tsugane, Shoichiro; Stram, Daniel O.; Marchand, Loïc Le

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Citation: Wang, H., T. Burnett, S. Kono, C. A. Haiman, M. Iwasaki, L. R. Wilkens, L. W. Loo, et al. 2014. “Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.” Nature communications 5 (1): 4613. doi:10.1038/ncomms5613. http://dx.doi.org/10.1038/ncomms5613.
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Abstract: The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P < 5×10−8) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4×10−9), providing additional insight into the etiology of CRC and highlighting the value of association mapping in diverse populations.
Published Version: doi:10.1038/ncomms5613
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180879/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:14065380
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