A new statistical approach to combining p-values using gamma distribution and its application to genome-wide association study

DSpace/Manakin Repository

A new statistical approach to combining p-values using gamma distribution and its application to genome-wide association study

Citable link to this page

 

 
Title: A new statistical approach to combining p-values using gamma distribution and its application to genome-wide association study
Author: Chen, Zhongxue; Yang, William; Liu, Qingzhong; Yang, Jack Y; Li, Jing; Yang, Mary Qu

Note: Order does not necessarily reflect citation order of authors.

Citation: Chen, Zhongxue, William Yang, Qingzhong Liu, Jack Y Yang, Jing Li, and Mary Qu Yang. 2014. “A new statistical approach to combining p-values using gamma distribution and its application to genome-wide association study.” BMC Bioinformatics 15 (Suppl 17): S3. doi:10.1186/1471-2105-15-S17-S3. http://dx.doi.org/10.1186/1471-2105-15-S17-S3.
Full Text & Related Files:
Abstract: Background: Combining information from different studies is an important and useful practice in bioinformatics, including genome-wide association study, rare variant data analysis and other set-based analyses. Many statistical methods have been proposed to combine p-values from independent studies. However, it is known that there is no uniformly most powerful test under all conditions; therefore, finding a powerful test in specific situation is important and desirable. Results: In this paper, we propose a new statistical approach to combining p-values based on gamma distribution, which uses the inverse of the p-value as the shape parameter in the gamma distribution. Conclusions: Simulation study and real data application demonstrate that the proposed method has good performance under some situations.
Published Version: doi:10.1186/1471-2105-15-S17-S3
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304193/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:14065442
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters