Bayesian meta-analysis for identifying periodically expressed genes in fission yeast cell cycle
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CitationFan, Xiaodan, Saumyadipta Pyne, and Jun S. Liu. 2010. “Bayesian Meta-Analysis for Identifying Periodically Expressed Genes in Fission Yeast Cell Cycle.” Annals of Applied Statistics 4, no. 2: 988–1013. doi:10.1214/09-aoas300.
AbstractThe effort to identify genes with periodic expression during the cell cycle from genome-wide microarray time series data has been ongoing for a decade. However, the lack of rigorous modeling of periodic expression as well as the lack of a comprehensive model for integrating information across genes and experiments has impaired the effort for the accurate identification of periodically expressed genes. To address the problem, we introduce a Bayesian model to integrate multiple independent microarray data sets from three recent genome-wide cell cycle studies on fission yeast. A hierarchical model was used for data integration. In order to facilitate an efficient Monte Carlo sampling from the joint posterior distribution, we develop a novel Metropolis–Hastings group move. A surprising finding from our integrated analysis is that more than 40% of the genes in fission yeast are significantly periodically expressed, greatly enhancing the reported 10–15% of the genes in the current literature. It calls for a reconsideration of the periodically expressed gene detection problem.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:14169386
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