Show simple item record

dc.contributor.authorLin, Eleanor
dc.contributor.authorMcCabe, Elizabeth
dc.contributor.authorNewton-Cheh, Christopher Holmes
dc.contributor.authorBloch, Kenneth Daniel
dc.contributor.authorBuys, Emmanuel
dc.contributor.authorWang, Thomas
dc.contributor.authorMiller, Karen Klahr
dc.date.accessioned2015-03-18T18:15:32Z
dc.date.issued2012
dc.identifier.citationLin, Eleanor, Elizabeth McCabe, Christopher Newton-Cheh, Kenneth Bloch, Emmanuel Buys, Thomas Wang, and Karen K. Miller. 2012. “Effects of Transdermal Testosterone on Natriuretic Peptide Levels in Women: a Randomized Placebo-Controlled Pilot Study.” Fertility and Sterility 97 (2) (February): 489–493. doi:10.1016/j.fertnstert.2011.11.001.en_US
dc.identifier.issn0015-0282en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:14229235
dc.description.abstractObjective: To investigate whether testosterone administration alters natriuretic peptide levels in women. Design: Three-month, double-blind, randomized, placebo-controlled study. Setting: Clinical research center. Patient(s): Fifty-one women with hypoandrogenemia due to hypopituitarism. Intervention(s): Transdermal testosterone (300 μg daily) or placebo patch. Main Outcome Measure(s): N-Terminal pro–B-type natriuretic peptide (NT-proBNP) levels. Result(s): NT-proBNP levels decreased in the transdermal testosterone group compared with placebo over three months. The difference between groups remained significant after controlling for baseline age, systolic blood pressure, body mass index, and homeostasis model assessment of insulin resistance. Change in NT-proBNP over 3 months was inversely associated with change in free testosterone levels. Conclusion(s): Testosterone administration to women results in decreased natriuretic peptide levels, suggesting that testosterone may be an inverse regulator of the natriuretic peptide system. Clinical Trials Registration Number: NCT00027430.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.fertnstert.2011.11.001en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269509/en_US
dash.licenseLAA
dc.subjectTestosteroneen_US
dc.subjectnatriuretic peptidesen_US
dc.titleEffects of transdermal testosterone on natriuretic peptide levels in women: a randomized placebo-controlled pilot studyen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalFertility and Sterilityen_US
dash.depositing.authorBuys, Emmanuel
dc.date.available2015-03-18T18:15:32Z
dc.identifier.doi10.1016/j.fertnstert.2011.11.001*
dash.contributor.affiliatedWang, Thomas Jue-Fuu
dash.contributor.affiliatedMiller, Karen
dash.contributor.affiliatedNewton-Cheh, Christopher
dash.contributor.affiliatedBuys, Emmanuel
dash.contributor.affiliatedBloch, Kenneth


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record