Pathophysiology of Hypertension in the Absence of Nitric Oxide/Cyclic GMP Signaling

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Pathophysiology of Hypertension in the Absence of Nitric Oxide/Cyclic GMP Signaling

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Title: Pathophysiology of Hypertension in the Absence of Nitric Oxide/Cyclic GMP Signaling
Author: Thoonen, Robrecht; Sips, Patrick; Bloch, Kenneth Daniel; Buys, Emmanuel

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Citation: Thoonen, Robrecht, Patrick Y. Sips, Kenneth D. Bloch, and Emmanuel S. Buys. 2012. “Pathophysiology of Hypertension in the Absence of Nitric Oxide/Cyclic GMP Signaling.” Curr Hypertens Rep 15 (1) (December 12): 47–58. doi:10.1007/s11906-012-0320-5.
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Abstract: The nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling system is a well-characterized modulator of cardiovascular function, in general, and blood pressure, in particular. The availability of mice mutant for key enzymes in the NO-cGMP signaling system facilitated the identification of interactions with other blood pressure modifying pathways (e.g. the renin-angiotensin-aldosterone system) and of gender-specific effects of impaired NO-cGMP signaling. In addition, recent genome-wide association studies identified blood pressure-modifying genetic variants in genes that modulate NO and cGMP levels. Together, these findings have advanced our understanding of how NO-cGMP signaling regulates blood pressure. In this review, we will summarize the results obtained in mice with disrupted NO-cGMP signaling and highlight the relevance of this pathway as a potential therapeutic target for the treatment of hypertension.
Published Version: doi:10.1007/s11906-012-0320-5
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544991/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:14229236
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