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dc.contributor.authorArora, Pankaj
dc.contributor.authorWu, Connie
dc.contributor.authorKhan, Abigail May
dc.contributor.authorBloch, Donald Bendit
dc.contributor.authorDavis-Dusenbery, Brandi Nicole
dc.contributor.authorGhorbani, Anahita
dc.contributor.authorSpagnolli, Ester
dc.contributor.authorMartinez, Andrew
dc.contributor.authorRyan, Allicia
dc.contributor.authorTainsh, Laurel T.
dc.contributor.authorKim, Samuel M
dc.contributor.authorRong, Jian
dc.contributor.authorHuan, Tianxiao
dc.contributor.authorFreedman, Jane E.
dc.contributor.authorLevy, Daniel
dc.contributor.authorMiller, Karen Klahr
dc.contributor.authorHata, Akiko
dc.contributor.authorDel Monte, Federica
dc.contributor.authorVandenwijngaert, Sara
dc.contributor.authorSwinnen, Melissa
dc.contributor.authorJanssens, Stefan
dc.contributor.authorHolmes, Tara M.
dc.contributor.authorBuys, Emmanuel
dc.contributor.authorBloch, Kenneth Daniel
dc.contributor.authorNewton-Cheh, Christopher Holmes
dc.contributor.authorWang, Thomas
dc.date.accessioned2015-03-18T19:41:07Z
dc.date.issued2013
dc.identifier.citationArora, Pankaj, Connie Wu, Abigail May Khan, Donald B. Bloch, Brandi N. Davis-Dusenbery, Anahita Ghorbani, Ester Spagnolli, et al. 2013. “Atrial Natriuretic Peptide Is Negatively Regulated by microRNA-425.” J. Clin. Invest. 123 (8) (July 15): 3378–3382. doi:10.1172/jci67383.en_US
dc.identifier.issn0021-9738en_US
dc.identifier.issn1558-8238en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:14229263
dc.description.abstractNumerous common genetic variants have been linked to blood pressure, but no underlying mechanism has been elucidated. Population studies have revealed that the variant rs5068 (A/G) in the 3′ untranslated region of NPPA, the gene encoding atrial natriuretic peptide (ANP), is associated with blood pressure. We selected individuals on the basis of rs5068 genotype (AG vs. AA) and fed them a low- or high-salt diet for 1 week, after which they were challenged with an intravenous saline infusion. On both diets, before and after saline administration, ANP levels were up to 50% higher in AG individuals than in AA individuals, a difference comparable to the changes induced by high-salt diet or saline infusion. In contrast, B-type natriuretic peptide levels did not differ by rs5068 genotype. We identified a microRNA, miR-425, that is expressed in human atria and ventricles and is predicted to bind the sequence spanning rs5068 for the A, but not the G, allele. miR-425 silenced NPPA mRNA in an allele-specific manner, with the G allele conferring resistance to miR-425. This study identifies miR-425 as a regulator of ANP production, raising the possibility that miR-425 antagonists could be used to treat disorders of salt overload, including hypertension and heart failure.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society for Clinical Investigationen_US
dc.relation.isversionofdoi:10.1172/JCI67383en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726159/en_US
dash.licenseLAA
dc.titleAtrial natriuretic peptide is negatively regulated by microRNA-425en_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of Clinical Investigationen_US
dash.depositing.authorBuys, Emmanuel
dc.date.available2015-03-18T19:41:07Z
dc.identifier.doi10.1172/JCI67383*
dash.authorsorderedfalse
dash.contributor.affiliatedSpagnolli, Ester
dash.contributor.affiliatedKim, Samuel M
dash.contributor.affiliatedWu, Connie
dash.contributor.affiliatedWang, Thomas Jue-Fuu
dash.contributor.affiliatedMiller, Karen
dash.contributor.affiliatedBloch, Kenneth
dash.contributor.affiliatedDel Monte, Federica
dash.contributor.affiliatedVandenwijngaert, Sara
dash.contributor.affiliatedBloch, Donald
dash.contributor.affiliatedBuys, Emmanuel
dash.contributor.affiliatedGhorbani, Anahita
dash.contributor.affiliatedNewton-Cheh, Christopher
dash.contributor.affiliatedArora, Pankaj
dash.contributor.affiliatedDavis-Dusenbery, Brandi N


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