Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino acid status

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Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino acid status

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Title: Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino acid status
Author: Lee, Byung Cheon; Kaya, Alaattin; Ma, Siming; Kim, Gwansu; Gerashchenko, Maxim V.; Yim, Sun Hee; Hu, Zhen; Harshman, Lawrence G.; Gladyshev, Vadim N.

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Citation: Lee, Byung Cheon, Alaattin Kaya, Siming Ma, Gwansu Kim, Maxim V. Gerashchenko, Sun Hee Yim, Zhen Hu, Lawrence G. Harshman, and Vadim N. Gladyshev. 2014. “Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino acid status.” Nature communications 5 (1): 3592. doi:10.1038/ncomms4592. http://dx.doi.org/10.1038/ncomms4592.
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Abstract: Reduced methionine (Met) intake can extend lifespan of rodents, but whether this regimen represents a general strategy for regulating aging has been controversial. Here we report that Met restriction extends lifespan in both fruit flies and yeast, and that this effect requires low amino acid status. Met restriction in Drosophila mimicks the effect of dietary restriction and is associated with decreased reproduction. However, under conditions of high amino acid status, Met restriction is ineffective and the trade-off between longevity and reproduction is not observed. Overexpression of InRDN or Tsc2 inhibits lifespan extension by Met restriction, suggesting the role of TOR signaling in the Met control of longevity. Overall, this study defines the specific roles of Met and amino acid imbalance in aging and suggests that Met restiction is a general strategy for lifespan extension.
Published Version: doi:10.1038/ncomms4592
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350766/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:14351048
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