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dc.contributor.authorFung, Jennyen_US
dc.contributor.authorGelaye, Bizuen_US
dc.contributor.authorQiu, Chunfangen_US
dc.contributor.authorZhong, Qiu-Yueen_US
dc.contributor.authorRondon, Marta Ben_US
dc.contributor.authorSanchez, Sixto Een_US
dc.contributor.authorBarrios, Yasmin Ven_US
dc.contributor.authorHevner, Karinen_US
dc.contributor.authorWilliams, Michelle Aen_US
dc.date.accessioned2015-04-01T15:26:01Z
dc.date.issued2015en_US
dc.identifier.citationFung, Jenny, Bizu Gelaye, Qiu-Yue Zhong, Marta B Rondon, Sixto E Sanchez, Yasmin V Barrios, Karin Hevner, Chunfang Qiu, and Michelle A Williams. 2015. “Association of decreased serum brain-derived neurotrophic factor (BDNF) concentrations in early pregnancy with antepartum depression.” BMC Psychiatry 15 (1): 43. doi:10.1186/s12888-015-0428-7. http://dx.doi.org/10.1186/s12888-015-0428-7.en
dc.identifier.issn1471-244Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:14351115
dc.description.abstractBackground: Antepartum depression is one of the leading causes of maternal morbidity and mortality in the prenatal period. There is accumulating evidence for the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression. The present study examines the extent to which maternal early pregnancy serum BDNF levels are associated with antepartum depression. Method A total of 968 women were recruited and interviewed in early pregnancy. Antepartum depression prevalence and symptom severity were assessed using the Patient Health Questionnaire-9 (PHQ-9) scale. Maternal serum BDNF levels were measured using a competitive enzyme-linked immunosorbent assay (ELISA). Logistic regression procedures were performed to estimate odds ratios (OR) and 95% confidence intervals (95% CI) adjusted for confounders. Results: Maternal early pregnancy serum BDNF levels were significantly lower in women with antepartum depression compared to women without depression (mean ± standard deviation [SD]: 20.78 ± 5.97 vs. 21.85 ± 6.42 ng/ml, p = 0.024). Lower BDNF levels were associated with increased odds of maternal antepartum depression. After adjusting for confounding, women whose serum BDNF levels were in the lowest three quartiles (<17.32 ng/ml) had 1.61-fold increased odds (OR = 1.61, 95% CI: 1.13, 2.30) of antepartum depression as compared with women whose BDNF levels were in the highest quartile (>25.31 ng/ml). There was no evidence of an association of BDNF levels with depression symptom severity. Conclusions: Lower maternal serum BDNF levels in early pregnancy are associated with antepartum depression. These findings may point toward new therapeutic opportunities and BDNF should be assessed as a potential biomarker for risk prediction and monitoring response to treatment for antepartum depression. Electronic supplementary material The online version of this article (doi:10.1186/s12888-015-0428-7) contains supplementary material, which is available to authorized users.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/s12888-015-0428-7en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364091/pdf/en
dash.licenseLAAen_US
dc.subjectPeruen
dc.subjectBiomarkeren
dc.subjectBDNFen
dc.subjectMaternal depressionen
dc.titleAssociation of decreased serum brain-derived neurotrophic factor (BDNF) concentrations in early pregnancy with antepartum depressionen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMC Psychiatryen
dash.depositing.authorGelaye, Bizuen_US
dc.date.available2015-04-01T15:26:01Z
dc.identifier.doi10.1186/s12888-015-0428-7*
dash.contributor.affiliatedWilliams, Michelle
dash.contributor.affiliatedGelaye, Bizu


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