Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations
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Author
Wu, Chen
Wang, Zhaoming
Song, Xin
Feng, Xiao-Shan
Abnet, Christian C.
He, Jie
Hu, Nan
Zuo, Xian-Bo
Tan, Wen
Zhan, Qimin
Hu, Zhibin
He, Zhonghu
Jia, Weihua
Zhou, Yifeng
Yu, Kai
Shu, Xiao-Ou
Yuan, Jian-Min
Zheng, Wei
Zhao, Xue-Ke
Gao, She-Gan
Yuan, Zhi-Qing
Zhou, Fu-You
Fan, Zong-Min
Cui, Ji-Li
Lin, Hong-Li
Han, Xue-Na
Li, Bei
Chen, Xi
Dawsey, Sanford M.
Liao, Linda
Lee, Maxwell P.
Ding, Ti
Qiao, You-Lin
Liu, Zhihua
Liu, Yu
Yu, Dianke
Chang, Jiang
Wei, Lixuan
Gao, Yu-Tang
Koh, Woon-Puay
Xiang, Yong-Bing
Tang, Ze-Zhong
Fan, Jin-Hu
Han, Jing-Jing
Zhou, Sheng-Li
Zhang, Peng
Zhang, Dong-Yun
Yuan, Yuan
Huang, Ying
Liu, Chunling
Zhai, Kan
Qiao, Yan
Jin, Guangfu
Guo, Chuanhai
Fu, Jianhua
Miao, Xiaoping
Lu, Changdong
Yang, Haijun
Wang, Chaoyu
Wheeler, William A.
Gail, Mitchell
Yeager, Meredith
Yuenger, Jeff
Guo, Er-Tao
Li, Ai-Li
Zhang, Wei
Li, Xue-Min
Sun, Liang-Dan
Ma, Bao-Gen
Li, Yan
Tang, Sa
Peng, Xiu-Qing
Liu, Jing
Hutchinson, Amy
Jacobs, Kevin
Giffen, Carol
Burdette, Laurie
Fraumeni, Joseph F.
Shen, Hongbing
Ke, Yang
Zeng, Yixin
Wu, Tangchun
Chung, Charles C.
Tucker, Margaret A.
Hou, Zhi-Chao
Liu, Ya-Li
Hu, Yan-Long
Wang, Li
Yuan, Guo
Chen, Li-Sha
Liu, Xiao
Ma, Teng
Meng, Hui
Sun, Li
Li, Xin-Min
Li, Xiu-Min
Ku, Jian-Wei
Zhou, Ying-Fa
Yang, Liu-Qin
Wang, Zhou
Li, Yin
Qige, Qirenwang
Yang, Wen-Jun
Lei, Guang-Yan
Chen, Long-Qi
Li, En-Min
Yuan, Ling
Yue, Wen-Bin
Wang, Ran
Wang, Lu-Wen
Fan, Xue-Ping
Zhu, Fang-Heng
Zhao, Wei-Xing
Mao, Yi-Min
Zhang, Mei
Xing, Guo-Lan
Li, Ji-Lin
Han, Min
Ren, Jing-Li
Liu, Bin
Ren, Shu-Wei
Kong, Qing-Peng
Li, Feng
Sheyhidin, Ilyar
Wei, Wu
Zhang, Yan-Rui
Feng, Chang-Wei
Wang, Jin
Yang, Yu-Hua
Hao, Hong-Zhang
Bao, Qi-De
Liu, Bao-Chi
Wu, Ai-Qun
Xie, Dong
Yang, Wan-Cai
Wang, Liang
Zhao, Xiao-Hang
Chen, Shu-Qing
Hong, Jun-Yan
Zhang, Xue-Jun
Freedman, Neal D
Goldstein, Alisa M.
Lin, Dongxin
Taylor, Philip R.
Wang, Li-Dong
Chanock, Stephen J.
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https://doi.org/10.1038/ng.3064Metadata
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Wu, C., Z. Wang, X. Song, X. Feng, C. C. Abnet, J. He, N. Hu, et al. 2014. “Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.” Nature genetics 46 (9): 1001-1006. doi:10.1038/ng.3064. http://dx.doi.org/10.1038/ng.3064.Abstract
We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) 1-3 of esophageal squamous cell carcinoma (ESCC) in ethnic Chinese (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study, and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% CI 0.82-0.88; P=7.72x10−20) and rs1642764 at 17p13.1 (per-allele OR= 0.88, 95% CI 0.85-0.91; P=3.10x10−13). rs7447927 is a synonymous single nucleotide polymorphism (SNP) in TMEM173 and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR=1.33, 95% CI 1.22-1.46; P=1.99x10−10). Our joint analysis identified new ESCC susceptibility loci overall as well as a new locus unique to the ESCC high risk Taihang Mountain region.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212832/pdf/Terms of Use
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