Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

 
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Wolpin, Brian M.
Rizzato, Cosmeri
Kooperberg, Charles
Petersen, Gloria M.
Wang, Zhaoming
Arslan, Alan A.
Beane-Freeman, Laura
Bracci, Paige M.
Canzian, Federico
Duell, Eric J.
Gallinger, Steven
Giles, Graham G.
Goodman, Gary E.
Goodman, Phyllis J.
Jacobs, Eric J.
Kamineni, Aruna
Klein, Alison P.
Kolonel, Laurence N.
Kulke, Matthew H.
Li, Donghui
Malats, Núria
Olson, Sara H.
Risch, Harvey A.
Visvanathan, Kala
White, Emily
Zheng, Wei
Abnet, Christian C.
Albanes, Demetrius
Andreotti, Gabriella
Austin, Melissa A.
Basso, Daniela
Berndt, Sonja I.
Boutron-Ruault, Marie-Christine
Brotzman, Michelle
Büchler, Markus W.
Bueno-de-Mesquita, H. Bas
Bugert, Peter
Burdette, Laurie
Campa, Daniele
Caporaso, Neil E.
Capurso, Gabriele
Chung, Charles
Cotterchio, Michelle
Costello, Eithne
Elena, Joanne
Funel, Niccola
Giese, Nathalia A.
Goggins, Michael
Gorman, Megan J.
Gross, Myron
Haiman, Christopher A.
Hassan, Manal
Helzlsouer, Kathy J.
Henderson, Brian E.
Holly, Elizabeth A.
Hu, Nan
Innocenti, Federico
Jenab, Mazda
Kaaks, Rudolf
Key, Timothy J.
Khaw, Kay-Tee
Klein, Eric A.
Kogevinas, Manolis
Krogh, Vittorio
Kupcinskas, Juozas
Kurtz, Robert C.
LaCroix, Andrea
Landi, Maria T.
Landi, Stefano
Le Marchand, Loic
Mambrini, Andrea
Mannisto, Satu
Milne, Roger L.
Nakamura, Yusuke
Oberg, Ann L.
Owzar, Kouros
Patel, Alpa V.
Peeters, Petra H. M.
Peters, Ulrike
Pezzilli, Raffaele
Piepoli, Ada
Porta, Miquel
Real, Francisco X.
Riboli, Elio
Rothman, Nathaniel
Scarpa, Aldo
Shu, Xiao-Ou
Silverman, Debra T.
Soucek, Pavel
Sund, Malin
Talar-Wojnarowska, Renata
Taylor, Philip R.
Theodoropoulos, George E.
Thornquist, Mark
Tjønneland, Anne
Tobias, Geoffrey S.
Trichopoulos, Dimitrios
Vodicka, Pavel
Wactawski-Wende, Jean
Wentzensen, Nicolas
Wu, Chen
Yu, Herbert
Yu, Kai
Zeleniuch-Jacquotte, Anne
Hoover, Robert
Hartge, Patricia
Chanock, Stephen J.
Stolzenberg-Solomon, Rachael S.
Amundadottir, Laufey T.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/ng.3052
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Wolpin, B. M., C. Rizzato, P. Kraft, C. Kooperberg, G. M. Petersen, Z. Wang, A. A. Arslan, et al. 2014. “Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.” Nature genetics 46 (9): 994-1000. doi:10.1038/ng.3052. http://dx.doi.org/10.1038/ng.3052.
Abstract
We performed a multistage genome-wide association study (GWAS) including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT; per-allele odds ratio [OR] = 0.79; 95% confidence interval [CI] = 0.74–0.84; P = 3.0×10−12), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2; OR = 1.46; 95% CI = 1.30–1.65; P = 1.1×10−10), rs9581943 at 13q12.2 (PDX1; OR = 1.15; 95% CI = 1.10–1.20; P = 2.4×10−9), and rs16986825 at 22q12.1 (ZNRF3; OR = 1.18; 95% CI = 1.12–1.25; P = 1.2×10−8). An independent signal was identified in exon 2 of TERT at the established region 5p15.33 (rs2736098; OR = 0.80; 95% CI = 0.76–0.85; P = 9.8×10−14). We also identified a locus at 8q24.21 (rs1561927; P = 1.3×10−7) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study has identified multiple new susceptibility alleles for pancreatic cancer worthy of follow-up studies.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191666/pdf/
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