The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development

DSpace/Manakin Repository

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development

Citable link to this page

 

 
Title: The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development
Author: Giera, Stefanie; Deng, Yiyu; Luo, Rong; Ackerman, Sarah D.; Mogha, Amit; Monk, Kelly R.; Ying, Yanqin; Jeong, Sung-Jin; Makinodan, Manabu; Bialas, Allison R.; Chang, Bernard S.; Stevens, Beth; Corfas, Gabriel; Piao, Xianhua

Note: Order does not necessarily reflect citation order of authors.

Citation: Giera, S., Y. Deng, R. Luo, S. D. Ackerman, A. Mogha, K. R. Monk, Y. Ying, et al. 2015. “The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development.” Nature Communications 6 (1): 6121. doi:10.1038/ncomms7121. http://dx.doi.org/10.1038/ncomms7121.
Full Text & Related Files:
Abstract: Mutations in GPR56, a member of the adhesion G protein-coupled receptor family, cause a human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). Magnetic resonance imaging (MRI) of BFPP brains reveals myelination defects in addition to brain malformation. However, the cellular role of GPR56 in oligodendrocyte development remains unknown. Here, we demonstrate that loss of Gpr56 leads to hypomyelination of the central nervous system in mice. GPR56 levels are abundant throughout early stages of oligodendrocyte development, but are downregulated in myelinating oligodendrocytes. Gpr56-knockout mice manifest with decreased oligodendrocyte precursor cell (OPC) proliferation and diminished levels of active RhoA, leading to fewer mature oligodendrocytes and a reduced number of myelinated axons in the corpus callosum and optic nerves. Conditional ablation of Gpr56 in OPCs leads to a reduced number of mature oligodendrocytes as seen in constitutive knockout of Gpr56. Together, our data define GPR56 as a cell-autonomous regulator of oligodendrocyte development.
Published Version: doi:10.1038/ncomms7121
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302951/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:14351225
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters