Quantitative Computed Tomographic Descriptors Associate Tumor Shape Complexity and Intratumor Heterogeneity with Prognosis in Lung Adenocarcinoma
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Author
Grove, Olya
Berglund, Anders E.
Schabath, Matthew B.
Dekker, Andre
Wang, Hua
Velazquez, Emmanuel Rios
Lambin, Philippe
Gu, Yuhua
Balagurunathan, Yoganand
Eikman, Edward
Gatenby, Robert A.
Eschrich, Steven
Gillies, Robert J.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1371/journal.pone.0118261Metadata
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Grove, O., A. E. Berglund, M. B. Schabath, H. J. W. L. Aerts, A. Dekker, H. Wang, E. R. Velazquez, et al. 2015. “Quantitative Computed Tomographic Descriptors Associate Tumor Shape Complexity and Intratumor Heterogeneity with Prognosis in Lung Adenocarcinoma.” PLoS ONE 10 (3): e0118261. doi:10.1371/journal.pone.0118261. http://dx.doi.org/10.1371/journal.pone.0118261.Abstract
Two CT features were developed to quantitatively describe lung adenocarcinomas by scoring tumor shape complexity (feature 1: convexity) and intratumor density variation (feature 2: entropy ratio) in routinely obtained diagnostic CT scans. The developed quantitative features were analyzed in two independent cohorts (cohort 1: n = 61; cohort 2: n = 47) of patients diagnosed with primary lung adenocarcinoma, retrospectively curated to include imaging and clinical data. Preoperative chest CTs were segmented semi-automatically. Segmented tumor regions were further subdivided into core and boundary sub-regions, to quantify intensity variations across the tumor. Reproducibility of the features was evaluated in an independent test-retest dataset of 32 patients. The proposed metrics showed high degree of reproducibility in a repeated experiment (concordance, CCC≥0.897; dynamic range, DR≥0.92). Association with overall survival was evaluated by Cox proportional hazard regression, Kaplan-Meier survival curves, and the log-rank test. Both features were associated with overall survival (convexity: p = 0.008; entropy ratio: p = 0.04) in Cohort 1 but not in Cohort 2 (convexity: p = 0.7; entropy ratio: p = 0.8). In both cohorts, these features were found to be descriptive and demonstrated the link between imaging characteristics and patient survival in lung adenocarcinoma.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349806/pdf/Terms of Use
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