Outlier-resilient complexity analysis of heartbeat dynamics

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Outlier-resilient complexity analysis of heartbeat dynamics

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Title: Outlier-resilient complexity analysis of heartbeat dynamics
Author: Lo, Men-Tzung; Chang, Yi-Chung; Lin, Chen; Young, Hsu-Wen Vincent; Lin, Yen-Hung; Ho, Yi-Lwun; Peng, Chung-Kang; Hu, Kun

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Citation: Lo, Men-Tzung, Yi-Chung Chang, Chen Lin, Hsu-Wen Vincent Young, Yen-Hung Lin, Yi-Lwun Ho, Chung-Kang Peng, and Kun Hu. 2015. “Outlier-resilient complexity analysis of heartbeat dynamics.” Scientific Reports 5 (1): 8836. doi:10.1038/srep08836. http://dx.doi.org/10.1038/srep08836.
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Abstract: Complexity in physiological outputs is believed to be a hallmark of healthy physiological control. How to accurately quantify the degree of complexity in physiological signals with outliers remains a major barrier for translating this novel concept of nonlinear dynamic theory to clinical practice. Here we propose a new approach to estimate the complexity in a signal by analyzing the irregularity of the sign time series of its coarse-grained time series at different time scales. Using surrogate data, we show that the method can reliably assess the complexity in noisy data while being highly resilient to outliers. We further apply this method to the analysis of human heartbeat recordings. Without removing any outliers due to ectopic beats, the method is able to detect a degradation of cardiac control in patients with congestive heart failure and a more degradation in critically ill patients whose life continuation relies on extracorporeal membrane oxygenator (ECMO). Moreover, the derived complexity measures can predict the mortality of ECMO patients. These results indicate that the proposed method may serve as a promising tool for monitoring cardiac function of patients in clinical settings.
Published Version: doi:10.1038/srep08836
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351527/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:14351245
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