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A Role for DOCK4 in Intestinal Barrier Properties
(2016-02-16)
Restoration of epithelial and endothelial barrier function is critical for tissue homeostasis. Yet, the molecular pathways response for modulating barrier properties remains largely unknown. This study investigates the ...
Evaluation of Cellular Mechanisms Involved in Recombinant Antibody Expression in Transiently Transfected Chinese Hamster Ovary Cells
(2016-05-02)
Transient recombinant antibody production in Chinese hamster ovary (CHO) cells is often used to screen large panels of candidates for potential therapeutic use. However, a significant proportion of antibodies express at a ...
A Novel Diagnostic Approach to Screen for Chemotherapy Drug Response in Non-Small Cell Lung Cancer Using Sortase Technology
(2016-05-02)
Drug resistance is the most significant barrier to improving long-term outcomes for patients with non-small cell lung cancer (NSCLC). Recent advances in the understanding of cell biology and molecular pathways have enabled ...
The Role and Effect of Antimicrobial Stewardship Programs Within the Hospital and How Rapid Diagnostics Can Make an Impact
(2016-05-02)
Rapid diagnostics paired with an active antimicrobial stewardship (ASP) can have a positive impact on patients and hospitals because it can provide pathogen identification and antimicrobial susceptibility results sooner ...
Using the CRISPR/Cas9 System to Derive an Isogenic BRCA1 Mutant (187delAG) Strain From a Wild Type BRCA1 Mammary Epithelial Strain
(2016-05-02)
A powerful new genomic engineering technique, the Clustered RegularInterspersed Short Palindromic Repeats (CRISPR), was co-opted from the immunesystem of bacteria and archaea, and uses specific guide RNAs to bring the ...
EpiProt: A Java Application Combining Protein Information With Epitope Prediction Software
(2016-11-10)
EpiProt is a bioinformatics suite designed to help users determine antigenic regions within proteins for the production of antibodies. It combines seven epitope prediction programs (five from the Immune Epitope Database, ...
Utilizing Brain Tumor Microenvironment to Propagate Pediatric Pilocytic Astrocytoma in Vitro and Test Novel Targeted Drug Therapies
(2018-04-09)
Pediatric brain tumors have recently surpassed leukemia as the leading cause of cancer related death in children (American Brain Tumor Association). Pilocytic astrocytoma (PA) is the most common type of primary central ...
Development of a High Throughput in Vitro Protein Localization Assay to Characterize Potentially Pathogenic Genetic Variants Associated With Retinitis Pigmentosa
(2016-09-06)
Retinitis pigmentosa is a disease comprised of a group of retinal degenerations (RD) that affects about 1/4,000 people worldwide (Wang, 2014). Currently, there is no cure for RP, and studying the disease is difficult because ...
Effects of Sample Processing Procedures on PBMC Gene Expression
(2016-06-30)
This study investigated the effects that sample processing had on PBMC gene expression profiles. Specifically, two vacutainer types were used in this study; sodium heparin CPT vacutainers and “standard” sodium heparin ...
On-Treatment DNA Damage Response Biomarkers in Surrogate Tissue Types
(2016-02-18)
Given the challenges associated with collection of tumor specimens for biomarker monitoring, collection of surrogate tissues (e.g., normal tissues such as hair or blood) may enable the assessment of pharmacodynamic (PD) ...