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A Role for DOCK4 in Intestinal Barrier Properties
(2016-02-16)
Restoration of epithelial and endothelial barrier function is critical for tissue homeostasis. Yet, the molecular pathways response for modulating barrier properties remains largely unknown. This study investigates the ...
Establishing Novel Immunoaffinity Purification Methods for Fusion Proteins
(2016-03-31)
The experiments in this thesis were performed to determine if novel uses of three fusion proteins could be established as a means of improving the protein purification process, and in particular, the elution step, thus ...
Creatine Assay for Use on Bench Top Chemistry Analyzer: Quick Analysis of Creatine in Human Serum Smaples
(2016-05-02)
Creatine (Cr) was initially discovered in the 1830s by a Frenchman named Chevreul. In subsequent years, it was discovered that creatine was utilized by the musculatory system, which fueled research on its overall use as a ...
Determining the Feasibility of a Liposomal Prototype Formulation for GC-C Agonist Peptide Drug Delivery
(2016-05-02)
The purpose of this study was to determine the feasibility of using a liposomal formulation for the systemic delivery of a GC-C agonist peptide drug. Peptide drugs have increased in numbers lately but are limited by ...
Characterization of the Effects of IVIg on CNS Inflammation Leading to Non-Classical Disease in a Relapsing Remitting Model of EAE
(2016-10-19)
Intravenous Immunoglobulin (IVIg) is a complex therapeutic used in the treatment of multiple autoimmune and inflammatory diseases. The mechanism of action of IVIg is pleiotropic; there is increasing evidence that modulation ...
Psychosocial Benefits of Yoga Training for Freshmen High School Students
(2016-06-14)
Stress in adolescents is a growing concern in the United States. The American Psychological Association has reported that teenagers are more stressed today than ever before (American Psychological Association, 2014 [APA]). ...
Effects of Sample Processing Procedures on PBMC Gene Expression
(2016-06-30)
This study investigated the effects that sample processing had on PBMC gene expression profiles. Specifically, two vacutainer types were used in this study; sodium heparin CPT vacutainers and “standard” sodium heparin ...
Understanding the Effects of Polydispersity on Protein Conjugation
(2016-12-01)
The level of polydispersity or aggregation in a protein population is an important factor to consider when performing conjugation or labeling reactions. In such reactions, the more aggregated portions of a polydispersed ...