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A Role for DOCK4 in Intestinal Barrier Properties
(2016-02-16)
Restoration of epithelial and endothelial barrier function is critical for tissue homeostasis. Yet, the molecular pathways response for modulating barrier properties remains largely unknown. This study investigates the ...
Effects of Sample Processing Procedures on PBMC Gene Expression
(2016-06-30)
This study investigated the effects that sample processing had on PBMC gene expression profiles. Specifically, two vacutainer types were used in this study; sodium heparin CPT vacutainers and “standard” sodium heparin ...
Development of a High Throughput Flow Cytometry Method to Analyze Changes in Epigenetic Histone Modifications in the Cell
(2018-01-12)
Epigenetic studies commonly include assays such as Chromatin Immunoprecipitation (ChIP), western blotting, and immunofluorescence (IF), which are used to measure changes in chromatin modifications and in DNA methylation ...
The Role of Chemokines CCL19b and CCL25b in T Cell Recruitment Into Melanoma Tumors.
(2017-08-24)
Malignant melanoma is an extremely metastatic cancer that is highly resistant to conventional therapy. One of the developing approaches to address melanoma involves immunotherapy. Immunotherapy involves harnessing the ...
Exploration of Non-Viral Gene Delivery Methods for Safe and Efficient Protein Expression in Non-Dividing Mammalian Cell Types
(2018-04-13)
Lentiviral vectors are a ubiquitous gene transfer tool in fundamental biological research. Although highly efficient and cost effective under most use cases, the limitations of lentivirus become apparent in specialized ...