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Progressive Changes in MOR1 in the Striatum of the Heterozygous Q175 Knock-in Mouse Model of Huntington's Disease
(2016-03-21)
Huntington’s disease (HD) is a progressive autosomal dominant neurodegenerative disease that produces pronounced neurodegeneration of neostriatal neurons as well as cortical neurons in HD patients. Despite the fact that ...
An Interactive Deep Learning Toolkit for Automatic Segmentation of Images
(2016-06-25)
This thesis presents the design, analysis, and implementation of an interactive deep learning toolkit to reduce the manual labeling effort and improve the automatic segmentation of image data. While deep neural networks ...
Development of a New Uniform File Format for Neuroscience Data Across the Globe
(2016-05-02)
With about 1011 neurons and about 1015 synaptic connections the human brain is among the most complex biologic systems ever observed (Rautenberg, Sobolev et al. 2011). Technical progress is driving the volume of data ...
The Dynamics of Hypothalamic Cell Proliferation in Mice
(2016-10-16)
Adult neurogenesis is the process by which new neurons are generated by neural stem cells (NSC) and are integrated into existing neural circuits in the adult brain. Contemporary research in adult neurogenesis in mammals ...
Characterization of the Effects of IVIg on CNS Inflammation Leading to Non-Classical Disease in a Relapsing Remitting Model of EAE
(2016-10-19)
Intravenous Immunoglobulin (IVIg) is a complex therapeutic used in the treatment of multiple autoimmune and inflammatory diseases. The mechanism of action of IVIg is pleiotropic; there is increasing evidence that modulation ...
Decreased Expression of the Protein Orhodenticle Homeobox 2 (Otx2) in Individuals With Schizophrenia: A Postmortem Investigation
(2016-06-22)
The purpose of this thesis was to determine if the amount of the protein Orthodenticle homeobox 2 (Otx2) is reduced in individuals with schizophrenia. Otx2 is a transcription factor that plays an essential role in the ...
Effect of Time and Sleep on the Transitive Inference Task
(2016-11-22)
Researchers seeking to understand the adaptive value of sleep have done so, in part, by assessing the cognitive effects of sleep on the performance of specific tasks. In this study we follow up on previous work reporting ...