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The Effects of Down-Regulation of MZB1 Expression on Apoptosis in Chronic Lymphocytic Leukemia B Cells With Mutations in the Splicing Factor 3b-1 Protein
(2017-02-02)
The goal of this work was to explore the role of the B cell specific Marginal Zone B and B1 cell (MZB1) protein in B cell viability and apoptosis with relation to mutations Splicing Factor 3B subunit 1 (SF3B1) protein, one ...
Evaluating the Role of ACTL6A and ACTL6B in the Pathogenesis of Polyomavirus Driven Merkel Cell Carcinoma
(2017-03-03)
Merkel Cell Carcinoma (MCC) is a rare (0.2 - 0.45 cases per 100,000) but extremely aggressive form of dermal neoplasm with a very poor prognosis. Approximately 53% MCCs occur in the head and neck, while 35% occur in the ...
Expression of Soluble Guanylate Cyclase in Rat and Human Hepatocytes
(2017-04-03)
Soluble Guanylate Cyclase (sGC) is a key enzyme in the nitric oxide (NO) signaling pathway. sGC binds NO to produce cyclic guanosine-3’,5’-monophosphate (cGMP). The NO-sGC-cGMP pathway is directly involved in a number ...
Characterizing the Effects of Takeda’s Inhibitor on the SREBP Family of Transcription Factors
(2017-06-02)
Sterol regulatory element-binding proteins (SREBPs) are a set of transcription factors that bind to the SRE element. This element is involved in regulating expression of genes involved in cholesterol and fatty acid synthesis ...
Differential Gene Expression and Pathway Analysis of Prx1-Expressing Cells in Calvarial Sutures and Long Bone Periosteum
(2017-04-17)
The Pair-related homeobox transcription factor (Prx1) is required for normal development of the cranium and axial skeleton. Prx1-expressing cells are found in the suture of the calvaria and periosteum of the long bones, ...
Determining the Role of Tubulointerstitial Nephritis Antigen-Like 1 in Renal Ischemic Reperfusion Injury
(2018-02-14)
Acute kidney injury (AKI) is a broad term that applies to a wide range of pathological etiologies characterized by a sudden increase in serum creatinine, a hallmark of malfunctioning kidneys. Ongoing efforts to elucidate ...
A Study of Differential Glycosylation of IgG on Fcγ Receptor Mediated Neutrophil Recruitment Model of SLE Nephritis
(2018-03-24)
The goal of this research was to evaluate cellular binding interactions to glycoengineered IgGs to further investigate the role neutrophils play in the pathogenesis of Lupus nephritis in an SLE nephritis model. Lupus ...
In Vivo Phenotypic Characterization of the Long Non-Coding RNA Kantr
(2017-11-14)
Non-coding regions of the human genome have just begun to be unraveled, and they hold the potential to be key regulators of biological mechanisms. The absence of a particular non-coding gene could be the answer to a disease ...
Amyloid Based Ceramic Biofilm and Its Applications in Building Materials
(2018-03-02)
Biofilm-Integrated Nanofiber Display (BIND) (Nguyen, Botyanszki, Tay, & Joshi, 2014a) is a platform for the engineering of the bacterial extracellular matrix material in amyloid. In this platform an engineered version of ...
Development of a High Throughput Flow Cytometry Method to Analyze Changes in Epigenetic Histone Modifications in the Cell
(2018-01-12)
Epigenetic studies commonly include assays such as Chromatin Immunoprecipitation (ChIP), western blotting, and immunofluorescence (IF), which are used to measure changes in chromatin modifications and in DNA methylation ...