Magneto-Fluorescent Core-Shell Supernanoparticles

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Author
Chen, Ou
Riedemann, Lars
Etoc, Fred
Herrmann, Hendrik
Coppey, Mathieu
Barch, Mariya
Zhao, Jing
Bruns, Oliver T.
Wei, He
Cui, Jian
Jensen, Russ
Chen, Yue
Harris, Daniel K.
Cordero, Jose M.
Wang, Zhongwu
Jasanoff, Alan
Reimer, Rudolph
Dahan, Maxime
Bawendi, Moungi G.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/ncomms6093Metadata
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Chen, O., L. Riedemann, F. Etoc, H. Herrmann, M. Coppey, M. Barch, C. T. Farrar, et al. 2014. “Magneto-Fluorescent Core-Shell Supernanoparticles.” Nature communications 5 (1): 5093. doi:10.1038/ncomms6093. http://dx.doi.org/10.1038/ncomms6093.Abstract
Magneto-fluorescent particles have been recognized as an emerging class of materials that exhibit great potential in advanced applications. However, synthesizing such magneto-fluorescent nanomaterials that simultaneously exhibit uniform and tunable sizes, high magnetic content loading, maximized fluorophore coverage at the surface, and a versatile surface functionality has proven challenging. Here we report a simple approach for co-assembling magnetic nanoparticles with fluorescent quantum dots to form colloidal magneto-fluorescent supernanoparticles. Importantly, these supernanoparticles exhibit a superstructure consisting of a close packed magnetic nanoparticle “core” which is fully surrounded by a “shell” of fluorescent quantum dots. A thin layer of silica-coating provides high colloidal stability and biocompatiblity and a versatile surface functionality. We demonstrate that after surface pegylation, these silica-coated magneto-fluorescent supernanoparticles can be magnetically manipulated inside living cells while being optically tracked. Moreover, our silica-coated magneto-fluorescent supernanoparticles can also serve as an in vivo multi-photon and magnetic resonance dual-modal imaging probe.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264679/pdf/Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:15034761
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