Magneto-Fluorescent Core-Shell Supernanoparticles
Bruns, Oliver T.
Harris, Daniel K.
Cordero, Jose M.
Bawendi, Moungi G.Note: Order does not necessarily reflect citation order of authors.
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CitationChen, O., L. Riedemann, F. Etoc, H. Herrmann, M. Coppey, M. Barch, C. T. Farrar, et al. 2014. “Magneto-Fluorescent Core-Shell Supernanoparticles.” Nature communications 5 (1): 5093. doi:10.1038/ncomms6093. http://dx.doi.org/10.1038/ncomms6093.
AbstractMagneto-fluorescent particles have been recognized as an emerging class of materials that exhibit great potential in advanced applications. However, synthesizing such magneto-fluorescent nanomaterials that simultaneously exhibit uniform and tunable sizes, high magnetic content loading, maximized fluorophore coverage at the surface, and a versatile surface functionality has proven challenging. Here we report a simple approach for co-assembling magnetic nanoparticles with fluorescent quantum dots to form colloidal magneto-fluorescent supernanoparticles. Importantly, these supernanoparticles exhibit a superstructure consisting of a close packed magnetic nanoparticle “core” which is fully surrounded by a “shell” of fluorescent quantum dots. A thin layer of silica-coating provides high colloidal stability and biocompatiblity and a versatile surface functionality. We demonstrate that after surface pegylation, these silica-coated magneto-fluorescent supernanoparticles can be magnetically manipulated inside living cells while being optically tracked. Moreover, our silica-coated magneto-fluorescent supernanoparticles can also serve as an in vivo multi-photon and magnetic resonance dual-modal imaging probe.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:15034761
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