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dc.contributor.authorMazumdar, Maitreyien_US
dc.contributor.authorIbne Hasan, Md Omar Sharifen_US
dc.contributor.authorHamid, Rezinaen_US
dc.contributor.authorValeri, Lindaen_US
dc.contributor.authorPaul, Ligien_US
dc.contributor.authorSelhub, Jacoben_US
dc.contributor.authorRodrigues, Ema Gen_US
dc.contributor.authorSilva, Fareesaen_US
dc.contributor.authorMia, Selimen_US
dc.contributor.authorMostofa, Md Golamen_US
dc.contributor.authorQuamruzzaman, Quazien_US
dc.contributor.authorRahman, Mahmuderen_US
dc.contributor.authorChristiani, David Cen_US
dc.date.accessioned2015-05-04T15:25:57Z
dc.date.issued2015en_US
dc.identifier.citationMazumdar, M., M. O. S. Ibne Hasan, R. Hamid, L. Valeri, L. Paul, J. Selhub, E. G. Rodrigues, et al. 2015. “Arsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladesh.” Environmental Health 14 (1): 34. doi:10.1186/s12940-015-0020-0. http://dx.doi.org/10.1186/s12940-015-0020-0.en
dc.identifier.issn1476-069Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:15034793
dc.description.abstractBackground: Arsenic induces neural tube defects in several animal models, but its potential to cause neural tube defects in humans is unknown. Our objective was to investigate the associations between maternal arsenic exposure, periconceptional folic acid supplementation, and risk of posterior neural tube defect (myelomeningocele) among a highly exposed population in rural Bangladesh. Methods: We performed a case–control study that recruited physician-confirmed cases from community health clinics served by Dhaka Community Hospital in Bangladesh, as well as local health facilities that treat children with myelomeningocele. Controls were selected from pregnancy registries in the same areas. Maternal arsenic exposure was estimated from drinking water samples taken from wells used during the first trimester of pregnancy. Periconceptional folic acid use was ascertained by self-report, and maternal folate status was further assessed by plasma folate levels measured at the time of the study visit. Results: Fifty-seven cases of myelomeningocele were identified along with 55 controls. A significant interaction was observed between drinking water inorganic arsenic and periconceptional folic acid use. As drinking water inorganic arsenic concentrations increased from 1 to 25 μg/L, the estimated protective effect of folic acid use declined (OR 0.22 to 1.03), and was not protective at higher concentrations of arsenic. No main effect of arsenic exposure on myelomeningocele risk was identified. Conclusions: Our study found a significant interaction between drinking water inorganic arsenic concentration from wells used during the first trimester of pregnancy and reported intake of periconceptional folic acid supplements. Results suggest that environmental arsenic exposure reduces the effectiveness of folic acid supplementation in preventing myelomeningocele.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/s12940-015-0020-0en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404044/pdf/en
dash.licenseLAAen_US
dc.subjectArsenicen
dc.subjectNeural tube defecten
dc.subjectMyelomeningoceleen
dc.subjectBirth defecten
dc.subjectFolate deficiencyen
dc.titleArsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladeshen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalEnvironmental Healthen
dash.depositing.authorValeri, Lindaen_US
dc.date.available2015-05-04T15:25:57Z
dc.identifier.doi10.1186/s12940-015-0020-0*
dash.authorsorderedfalse
dash.contributor.affiliatedRodrigues, Ema
dash.contributor.affiliatedValeri, Linda
dash.contributor.affiliatedChristiani, David


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