Show simple item record

dc.contributor.authorLi, Jonathan Z.en_US
dc.contributor.authorArnold, Kelly B.en_US
dc.contributor.authorLo, Janeten_US
dc.contributor.authorDugast, Anne-Sophieen_US
dc.contributor.authorPlants, Jillen_US
dc.contributor.authorRibaudo, Heather J.en_US
dc.contributor.authorCesa, Kevinen_US
dc.contributor.authorHeisey, Andreaen_US
dc.contributor.authorKuritzkes, Daniel R.en_US
dc.contributor.authorLauffenburger, Douglas A.en_US
dc.contributor.authorAlter, Galiten_US
dc.contributor.authorLanday, Alanen_US
dc.contributor.authorGrinspoon, Stevenen_US
dc.contributor.authorPereyra, Florenciaen_US
dc.date.accessioned2015-05-04T15:26:03Z
dc.date.issued2014en_US
dc.identifier.citationLi, J. Z., K. B. Arnold, J. Lo, A. Dugast, J. Plants, H. J. Ribaudo, K. Cesa, et al. 2014. “Differential Levels of Soluble Inflammatory Markers by Human Immunodeficiency Virus Controller Status and Demographics.” Open Forum Infectious Diseases 2 (1): ofu117. doi:10.1093/ofid/ofu117. http://dx.doi.org/10.1093/ofid/ofu117.en
dc.identifier.issn2328-8957en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:15034809
dc.description.abstractBackground. Human immunodeficiency virus (HIV)-1 elite controllers (ECs) represent an ideal population to study the effects of HIV persistence on chronic inflammation in the absence of antiretroviral therapy (ART). Methods. Twenty inflammatory markers measured in cohorts of ECs, HIV suppressed noncontrollers, and HIV-uninfected controls were compared using rank-based tests and partial least squares discriminant analysis (PLSDA). Spearman correlations were determined among the inflammatory markers, residual viremia by the single-copy assay, and CD4+ T cell slope. Results. Significant differences were seen between cohorts in 15 of the soluble inflammatory markers. Human immunodeficiency virus-1 ECs were found to have the highest levels for all of the markers with the exception of RANTES. In particular, median levels of 7 inflammatory markers (soluble CD14 [sCD14], interferon [IFN]-γ, IFN-γ-inducible protein [IP]-10, interleukin [IL]-4, IL-10, sCD40L, and granulocyte-macrophage colony-stimulating factor) were twice as high in the HIV-1 ECs compared with either of the HIV-suppressed or uninfected groups. Multivariate PLSDA analysis of inflammatory markers improved differentiation between the patient cohorts, discerning gender differences in inflammatory profile amongst individuals on suppressive ART. Soluble markers of inflammation in ECs were not associated with either levels of residual HIV-1 viremia or CD4+ T cell decline. Conclusions. Despite maintaining relatively low levels of viremia, HIV-1 ECs had elevated levels of a set of key inflammatory markers. Additional studies are needed to determine whether ECs may benefit from ART and to further evaluate the observed gender differences.en
dc.language.isoen_USen
dc.publisherOxford University Pressen
dc.relation.isversionofdoi:10.1093/ofid/ofu117en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396431/pdf/en
dash.licenseLAAen_US
dc.subjectantiretroviral therapyen
dc.subjectgenderen
dc.subjectHIV elite controllersen
dc.subjectinflammationen
dc.subjectlow-level viremiaen
dc.titleDifferential Levels of Soluble Inflammatory Markers by Human Immunodeficiency Virus Controller Status and Demographicsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalOpen Forum Infectious Diseasesen
dash.depositing.authorLi, Jonathan Z.en_US
dc.date.available2015-05-04T15:26:03Z
dc.identifier.doi10.1093/ofid/ofu117*
dash.authorsorderedfalse
dash.contributor.affiliatedRibaudo, Heather
dash.contributor.affiliatedGrinspoon, Steven
dash.contributor.affiliatedKuritzkes, Daniel
dash.contributor.affiliatedLo, Janet
dash.contributor.affiliatedLi, Jonathan
dash.contributor.affiliatedPereyra, F


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record