Show simple item record

dc.contributor.authorCohen, Jeremiah Yen_US
dc.contributor.authorAmoroso, Mackenzie Wen_US
dc.contributor.authorUchida, Naoshigeen_US
dc.date.accessioned2015-05-04T15:26:58Z
dc.date.issued2015en_US
dc.identifier.citationCohen, Jeremiah Y, Mackenzie W Amoroso, and Naoshige Uchida. 2015. “Serotonergic neurons signal reward and punishment on multiple timescales.” eLife 4 (1): e06346. doi:10.7554/eLife.06346. http://dx.doi.org/10.7554/eLife.06346.en
dc.identifier.issn2050-084Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:15034876
dc.description.abstractSerotonin's function in the brain is unclear. One challenge in testing the numerous hypotheses about serotonin's function has been observing the activity of identified serotonergic neurons in animals engaged in behavioral tasks. We recorded the activity of dorsal raphe neurons while mice experienced a task in which rewards and punishments varied across blocks of trials. We ‘tagged’ serotonergic neurons with the light-sensitive protein channelrhodopsin-2 and identified them based on their responses to light. We found three main features of serotonergic neuron activity: (1) a large fraction of serotonergic neurons modulated their tonic firing rates over the course of minutes during reward vs punishment blocks; (2) most were phasically excited by punishments; and (3) a subset was phasically excited by reward-predicting cues. By contrast, dopaminergic neurons did not show firing rate changes across blocks of trials. These results suggest that serotonergic neurons signal information about reward and punishment on multiple timescales. DOI: http://dx.doi.org/10.7554/eLife.06346.001en
dc.language.isoen_USen
dc.publishereLife Sciences Publications, Ltden
dc.relation.isversionofdoi:10.7554/eLife.06346en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389268/pdf/en
dash.licenseLAAen_US
dc.subjectneurophysiologyen
dc.subjectrewarden
dc.subjectpunishmenten
dc.subjectbehavioren
dc.subjectserotoninen
dc.subjectdorsal rapheen
dc.subjectmouseen
dc.titleSerotonergic neurons signal reward and punishment on multiple timescalesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journaleLifeen
dash.depositing.authorAmoroso, Mackenzie Wen_US
dc.date.available2015-05-04T15:26:58Z
dc.identifier.doi10.7554/eLife.06346*
dash.contributor.affiliatedMathis, Mackenzie
dash.contributor.affiliatedUchida, Naoshige


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record