Show simple item record

dc.contributor.authorWalford, Geoffrey A.en_US
dc.contributor.authorColomo, Nataliaen_US
dc.contributor.authorTodd, Jennifer N.en_US
dc.contributor.authorBillings, Liana K.en_US
dc.contributor.authorFernandez, Marleneen_US
dc.contributor.authorChamarthi, Binduen_US
dc.contributor.authorWarner, A. Sofiaen_US
dc.contributor.authorDavis, Jaclynen_US
dc.contributor.authorLittleton, Katherine R.en_US
dc.contributor.authorHernandez, Alicia M.en_US
dc.contributor.authorFanelli, Rebecca R.en_US
dc.contributor.authorLanier, Ameliaen_US
dc.contributor.authorBarbato, Corinneen_US
dc.contributor.authorAckerman, Rachel J.en_US
dc.contributor.authorKhan, Sabina Q.en_US
dc.contributor.authorBui, Rosaen_US
dc.contributor.authorGarber, Laurelen_US
dc.contributor.authorStolerman, Elliot S.en_US
dc.contributor.authorMoore, Allan F.en_US
dc.contributor.authorHuang, Chunmeien_US
dc.contributor.authorKaur, Varinderpalen_US
dc.contributor.authorHarden, Maeganen_US
dc.contributor.authorTaylor, Andrewen_US
dc.contributor.authorChen, Lingen_US
dc.contributor.authorManning, Alisa K.en_US
dc.contributor.authorHuang, Paulen_US
dc.contributor.authorWexler, Deborahen_US
dc.contributor.authorMcCarthy, Rita M.en_US
dc.contributor.authorLo, Janeten_US
dc.contributor.authorThomas, Melissa K.en_US
dc.contributor.authorGrant, Richard W.en_US
dc.contributor.authorGoldfine, Allisonen_US
dc.contributor.authorHudson, Margo S.en_US
dc.contributor.authorFlorez, Jose C.en_US
dc.date.accessioned2015-05-04T15:27:02Z
dc.date.issued2015en_US
dc.identifier.citationWalford, G. A., N. Colomo, J. N. Todd, L. K. Billings, M. Fernandez, B. Chamarthi, A. S. Warner, et al. 2015. “The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes.” PLoS ONE 10 (3): e0121553. doi:10.1371/journal.pone.0121553. http://dx.doi.org/10.1371/journal.pone.0121553.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:15034879
dc.description.abstractObjective: Genome-wide association studies have uncovered a large number of genetic variants associated with type 2 diabetes or related phenotypes. In many cases the causal gene or polymorphism has not been identified, and its impact on response to anti-hyperglycemic medications is unknown. The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH, NCT01762046) is a novel resource of genetic and biochemical data following glipizide and metformin administration. We describe recruitment, enrollment, and phenotyping procedures and preliminary results for the first 668 of our planned 1,000 participants enriched for individuals at risk of requiring anti-diabetic therapy in the future. Methods: All individuals are challenged with 5 mg glipizide × 1; twice daily 500 mg metformin × 2 days; and 75-g oral glucose tolerance test following metformin. Genetic variants associated with glycemic traits and blood glucose, insulin, and other hormones at baseline and following each intervention are measured. Results: Approximately 50% of the cohort is female and 30% belong to an ethnic minority group. Following glipizide administration, peak insulin occurred at 60 minutes and trough glucose at 120 minutes. Thirty percent of participants experienced non-severe symptomatic hypoglycemia and required rescue with oral glucose. Following metformin administration, fasting glucose and insulin were reduced. Common genetic variants were associated with fasting glucose levels. Conclusions: SUGAR-MGH represents a viable pharmacogenetic resource which, when completed, will serve to characterize genetic influences on pharmacological perturbations, and help establish the functional relevance of newly discovered genetic loci to therapy of type 2 diabetes. Trial Registration ClinicalTrials.gov NCT01762046en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0121553en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374872/pdf/en
dash.licenseLAAen_US
dc.titleThe Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorWalford, Geoffrey A.en_US
dc.date.available2015-05-04T15:27:02Z
dc.identifier.doi10.1371/journal.pone.0121553*
dash.authorsorderedfalse
dash.contributor.affiliatedManning, Alisa
dash.contributor.affiliatedTodd, Jennifer
dash.contributor.affiliatedChamarthi, Bindu
dash.contributor.affiliatedDavis, Jaclyn
dash.contributor.affiliatedHuang, Chunmei
dash.contributor.affiliatedWexler, Deborah
dash.contributor.affiliatedHudson, Margo
dash.contributor.affiliatedLo, Janet
dash.contributor.affiliatedGoldfine, Allison B.
dash.contributor.affiliatedWalford, Geoffrey A.
dash.contributor.affiliatedHuang, Paul
dash.contributor.affiliatedFlorez, Jose


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record