Inositol Phosphate Recycling Regulates Glycolytic and Lipid Metabolism That Drives Cancer Aggressiveness

DSpace/Manakin Repository

Inositol Phosphate Recycling Regulates Glycolytic and Lipid Metabolism That Drives Cancer Aggressiveness

Citable link to this page

 

 
Title: Inositol Phosphate Recycling Regulates Glycolytic and Lipid Metabolism That Drives Cancer Aggressiveness
Author: Benjamin, Daniel I.; Louie, Sharon M.; Mulvihill, Melinda M.; Kohnz, Rebecca A.; Li, Daniel S.; Chan, Lauryn G.; Sorrentino, Antonio; Bandyopadhyay, Sourav; Cozzo, Alyssa; Ohiri, Anayo; Goga, Andrei; Ng, Shu-Wing; Nomura, Daniel K.

Note: Order does not necessarily reflect citation order of authors.

Citation: Benjamin, D., S. M. Louie, M. M. Mulvihill, R. A. Kohnz, D. S. Li, L. G. Chan, A. Sorrentino, et al. 2014. “Inositol Phosphate Recycling Regulates Glycolytic and Lipid Metabolism That Drives Cancer Aggressiveness.” ACS Chemical Biology 9 (6): 1340-1350. doi:10.1021/cb5001907. http://dx.doi.org/10.1021/cb5001907.
Full Text & Related Files:
Abstract: Cancer cells possess fundamentally altered metabolism that supports their pathogenic features, which includes a heightened reliance on aerobic glycolysis to provide precursors for synthesis of biomass. We show here that inositol polyphosphate phosphatase 1 (INPP1) is highly expressed in aggressive human cancer cells and primary high-grade human tumors. Inactivation of INPP1 leads to a reduction in glycolytic intermediates that feed into the synthesis of the oncogenic signaling lipid lysophosphatidic acid (LPA), which in turn impairs LPA signaling and further attenuates glycolytic metabolism in a feed-forward mechanism to impair cancer cell motility, invasiveness, and tumorigenicity. Taken together these findings reveal a novel mode of glycolytic control in cancer cells that can serve to promote key oncogenic lipid signaling pathways that drive cancer pathogenicity.
Published Version: doi:10.1021/cb5001907
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076040/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:15034927
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters