dc.contributor.author | Benjamin, Daniel
I. | en_US |
dc.contributor.author | Louie, Sharon M. | en_US |
dc.contributor.author | Mulvihill, Melinda M. | en_US |
dc.contributor.author | Kohnz, Rebecca A. | en_US |
dc.contributor.author | Li, Daniel S. | en_US |
dc.contributor.author | Chan, Lauryn G. | en_US |
dc.contributor.author | Sorrentino, Antonio | en_US |
dc.contributor.author | Bandyopadhyay, Sourav | en_US |
dc.contributor.author | Cozzo, Alyssa | en_US |
dc.contributor.author | Ohiri, Anayo | en_US |
dc.contributor.author | Goga, Andrei | en_US |
dc.contributor.author | Ng, Shu-Wing | en_US |
dc.contributor.author | Nomura, Daniel K. | en_US |
dc.date.accessioned | 2015-05-04T15:27:23Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Benjamin, D., S. M. Louie, M. M. Mulvihill, R. A. Kohnz, D. S. Li, L. G. Chan, A. Sorrentino, et al. 2014. “Inositol Phosphate Recycling Regulates Glycolytic and Lipid Metabolism That Drives Cancer Aggressiveness.” ACS Chemical Biology 9 (6): 1340-1350. doi:10.1021/cb5001907. http://dx.doi.org/10.1021/cb5001907. | en |
dc.identifier.issn | 1554-8929 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:15034927 | |
dc.description.abstract | Cancer cells possess fundamentally altered metabolism that supports their pathogenic features, which includes a heightened reliance on aerobic glycolysis to provide precursors for synthesis of biomass. We show here that inositol polyphosphate phosphatase 1 (INPP1) is highly expressed in aggressive human cancer cells and primary high-grade human tumors. Inactivation of INPP1 leads to a reduction in glycolytic intermediates that feed into the synthesis of the oncogenic signaling lipid lysophosphatidic acid (LPA), which in turn impairs LPA signaling and further attenuates glycolytic metabolism in a feed-forward mechanism to impair cancer cell motility, invasiveness, and tumorigenicity. Taken together these findings reveal a novel mode of glycolytic control in cancer cells that can serve to promote key oncogenic lipid signaling pathways that drive cancer pathogenicity. | en |
dc.language.iso | en_US | en |
dc.publisher | American Chemical
Society | en |
dc.relation.isversionof | doi:10.1021/cb5001907 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076040/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Articles | en |
dc.title | Inositol Phosphate Recycling Regulates Glycolytic and Lipid Metabolism That Drives Cancer Aggressiveness | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | ACS Chemical Biology | en |
dash.depositing.author | Ng, Shu-Wing | en_US |
dc.date.available | 2015-05-04T15:27:23Z | |
dc.identifier.doi | 10.1021/cb5001907 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Ng, Shu-Wing | |