EMT and tumor metastasis

View/ Open
Author
Heerboth, Sarah
Housman, Genevieve
Leary, Meghan
Byler, Shannon
Lapinska, Karolina
Willbanks, Amber
Sarkar, Sibaji
Published Version
https://doi.org/10.1186/s40169-015-0048-3Metadata
Show full item recordCitation
Heerboth, Sarah, Genevieve Housman, Meghan Leary, Mckenna Longacre, Shannon Byler, Karolina Lapinska, Amber Willbanks, and Sibaji Sarkar. 2015. “EMT and tumor metastasis.” Clinical and Translational Medicine 4 (1): 6. doi:10.1186/s40169-015-0048-3. http://dx.doi.org/10.1186/s40169-015-0048-3.Abstract
EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these processes and the molecular pathways that contribute to them. First, we compare embryogenesis and development with cancer metastasis. We then discuss the signaling pathways and the differential expression and down-regulation of receptors in both tumor cells and stromal cells, which play a role in EMT and metastasis. We further delve into the clinical implications of EMT and MET in several types of tumors, and lastly, we discuss the role of epigenetic events that regulate EMT/MET processes. We hypothesize that reversible epigenetic events regulate both EMT and MET, and thus, also regulate the development of different types of metastatic cancers.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385028/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:15034934
Collections
- HMS Scholarly Articles [17852]
Contact administrator regarding this item (to report mistakes or request changes)