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dc.contributor.authorHeerboth, Sarahen_US
dc.contributor.authorHousman, Genevieveen_US
dc.contributor.authorLeary, Meghanen_US
dc.contributor.authorLongacre, Mckennaen_US
dc.contributor.authorByler, Shannonen_US
dc.contributor.authorLapinska, Karolinaen_US
dc.contributor.authorWillbanks, Amberen_US
dc.contributor.authorSarkar, Sibajien_US
dc.date.accessioned2015-05-04T15:27:26Z
dc.date.issued2015en_US
dc.identifier.citationHeerboth, Sarah, Genevieve Housman, Meghan Leary, Mckenna Longacre, Shannon Byler, Karolina Lapinska, Amber Willbanks, and Sibaji Sarkar. 2015. “EMT and tumor metastasis.” Clinical and Translational Medicine 4 (1): 6. doi:10.1186/s40169-015-0048-3. http://dx.doi.org/10.1186/s40169-015-0048-3.en
dc.identifier.issn2001-1326en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:15034934
dc.description.abstractEMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these processes and the molecular pathways that contribute to them. First, we compare embryogenesis and development with cancer metastasis. We then discuss the signaling pathways and the differential expression and down-regulation of receptors in both tumor cells and stromal cells, which play a role in EMT and metastasis. We further delve into the clinical implications of EMT and MET in several types of tumors, and lastly, we discuss the role of epigenetic events that regulate EMT/MET processes. We hypothesize that reversible epigenetic events regulate both EMT and MET, and thus, also regulate the development of different types of metastatic cancers.en
dc.language.isoen_USen
dc.publisherSpringer Berlin Heidelbergen
dc.relation.isversionofdoi:10.1186/s40169-015-0048-3en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385028/pdf/en
dash.licenseLAAen_US
dc.titleEMT and tumor metastasisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalClinical and Translational Medicineen
dash.depositing.authorLongacre, Mckennaen_US
dc.date.available2015-05-04T15:27:26Z
dc.identifier.doi10.1186/s40169-015-0048-3*
dash.contributor.affiliatedLongacre, McKenna


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